1-Benzhydryl-4-(3-methyl-5-nitroimidazol-4-yl)piperazine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Benzhydryl-4-(3-methyl-5-nitroimidazol-4-yl)piperazine
• 化学式: C21H23N5O2
• 分子量: 377.4
• InChiKey: VIBCTSRTAAHZQU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  70.1
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• COMPOSITIONS FOR THE TREATMENT OF HYPERPHENYLALANINEMIA
  申请人：Pey Rodríguez Ángel

  公开号：US20100286166A1

  公开（公告）日：2010-11-11

  The present invention relates to the use of specific types of compounds acting as pharmacological chaperones having a stabilizing activity on the phenylalanine hydroxylase (PAH) enzyme for the prophylaxis and/or treatment of hyperphenylalaninemia (HPA) and phenylketonuria PKU) and diseases, disorders and conditions related thereto. Further, the present invention relates to pharmaceutical compositions containing the compounds according to the present invention as well as to methods of treatment of HPA, in particular, PKU and diseases, disorders and conditions related thereto.

  本发明涉及使用具有稳定苯丙氨酸羟化酶（PAH）酶活性的特定化合物作为药理伴侣，用于预防和/或治疗高苯丙氨酸血症（HPA）和苯丙酮尿症（PKU）以及相关疾病、障碍和病况。此外，本发明还涉及含有本发明化合物的药物组合物，以及治疗HPA，特别是PKU以及相关疾病、障碍和病况的方法。
• Compositions for the treatment of hyperphenylalaninemia
  申请人：Bergen Teknologioverforing AS

  公开号：EP2008656A1

  公开（公告）日：2008-12-31

  The present invention relates to the use of specific types of compounds acting as pharmacological chaperones having a stabilizing activity on the phenylalanine hydroxylase (PAH) enzyme for the prophylaxis and/or treatment of hyperphenylalaninemia (HPA) and phenylketonuria (PKU) and diseases, disorders and conditions related thereto. Further, the present invention relates to pharmaceutical compositions containing the compounds according to the present invention as well as to methods of treatment of HPA, in particular, PKU and diseases, disorders and conditions related thereto.

  本发明涉及作为对苯丙氨酸羟化酶（PAH）酶具有稳定活性的药理伴侣的特定类型化合物在预防和/或治疗高苯丙氨酸血症（HPA）和苯丙酮尿症（PKU）以及与之相关的疾病、紊乱和病症方面的用途。此外，本发明还涉及含有根据本发明的化合物的药物组合物，以及治疗高苯丙氨酸血症（HPA），尤其是高苯丙氨酸尿症（PKU）和与之相关的疾病、失调和病症的方法。
• US8338423B2
  申请人：——

  公开号：US8338423B2

  公开（公告）日：2012-12-25
• [EN] COMPOSITIONS FOR THE TREATMENT OF HYPERPHENYLALANINEMIA<br/>[FR] COMPOSITIONS POUR LE TRAITEMENT DE L'HYPERPHÉNYLALANINÉMIE
  申请人：UNIV ZARAGOZA

  公开号：WO2009000552A2

  公开（公告）日：2008-12-31

  [EN] The present invention relates to the use of specific types of compounds acting as pharmacological chaperones having a stabilizing activity op the phenylalanine hydroxylase (PAH) enzyme for the prophylaxis and/or treatment of hyperphenylalaninemia (HPA) and phenylketonuria (PKU) and diseases, disorders and conditions related thereto. Further, the present invention relates to pharmaceutical compositions containing the compounds according to the present invention as well as to methods of treatment of HPA, in particular, PKU and diseases, disorders and conditions related thereto.
  [FR] La présente invention concerne l'utilisation de types spécifiques de composés agissant en tant que chaperons pharmacologiques qui présentent une activité stabilisatrice de l'enzyme phénylalanine hydroxylase (PAH) et sont destinés à la prophylaxie et/ou au traitement de l'hyperphénylalaninémie (HPA) et de la phénylcétonurie (PCU) ainsi que de maladies, de troubles et de pathologies connexes. La présente invention concerne en outre des compositions pharmaceutiques contenant les composés selon la présente invention ainsi que des procédés de traitement de la HPA, en particulier, de la PCU ainsi que de maladies, de troubles et de pathologies connexes.