1-Ethenylsulfonyl-2-nitro-4-(trifluoromethyl)benzene | 685119-64-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Ethenylsulfonyl-2-nitro-4-(trifluoromethyl)benzene
• CAS: 685119-64-6
• 化学式: C9H6F3NO4S
• mdl: MFCD04110779
• 分子量: 281.21
• InChiKey: CFFVGBUPXOHVRI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.111
• 拓扑面积：
  88.3
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• [EN] 4-SUBSTITUTED 1-ETHENYLSULFONYL-2-NITROBENZENE COMPOUNDS FOR TREATING SYNUCLEINOPATHIES<br/>[FR] COMPOSÉS DE 1-ÉTHÉNYLSULFONYL-2-NITROBENZÈNE À SUBSTITUTION EN POSITION 4 POUR LE TRAITEMENT DE SYNUCLÉINOPATHIES
  申请人：UNIV BARCELONA AUTONOMA

  公开号：WO2019161917A1

  公开（公告）日：2019-08-29

  The invention relates to compounds of formula I able to inhibit α- synuclein aggregation, their use in the treatment or prophylaxis of a synucleinopathy and to pharmaceutical compositions comprising said compounds of formula I : wherein R is selected from C1-C4-alkyl or cyclopropyl, wherein up to three hydrogen atoms of the C1-C4-alkyl or of the cyclopropyl are optionally substituted by radicals which are independently selected from F, CI, OH and NH2, provided there are no geminally bound OH groups if two or three OH groups are present.