4-[(2,2-dimethyl-4-oxo-3H-thiopyran-6-yl)sulfanyl]-3-nitrobenzonitrile

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[(2,2-dimethyl-4-oxo-3H-thiopyran-6-yl)sulfanyl]-3-nitrobenzonitrile
• 化学式: C14H12N2O3S2
• 分子量: 320.4
• InChiKey: LCYOYGCMOWJJHW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  137
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• HIF inhibitors and use thereof
  申请人：The General Hospital Corporation

  公开号：US10881656B2

  公开（公告）日：2021-01-05

  The present invention is directed to HIF inhibitors and methods of preventing cell proliferation, reducing inflammation, and treating an angiogenic disease or disorders.

  本发明涉及 HIF 抑制剂以及防止细胞增殖、减少炎症和治疗血管生成疾病或紊乱的方法。
• AGENTS AND METHODS FOR TREATING ISCHEMIC AND OTHER DISEASES
  申请人：Sun Xiujun

  公开号：US20110251182A1

  公开（公告）日：2011-10-13

  This invention relates to methods of screening for modulators of mammalian cell injury cause by TRPM7 gene and protein activity, compounds that modulate TRPM7 gene and protein activity and methods of treatment of mammalian cell injury using modulators of TRPM7 gene and protein activity.
• HIF INHIBITORS AND USE THEREOF
  申请人：Iliopoulos Othon

  公开号：US20120070369A1

  公开（公告）日：2012-03-22

  The present invention is directed to HIF inhibitors and methods of preventing cell proliferation, reducing inflammation, and treating an angiogenic disease or disorders.
• US9604958B2
  申请人：——

  公开号：US9604958B2

  公开（公告）日：2017-03-28
• US9566284B2
  申请人：——

  公开号：US9566284B2

  公开（公告）日：2017-02-14