6-Benzyloxy-7-methoxy-2H-chromene | 336131-14-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 6-Benzyloxy-7-methoxy-2H-chromene
• 英文别名: 7-methoxy-6-phenylmethoxy-2H-chromene
• CAS: 336131-14-7
• 化学式: C₁₇H₁₆O₃
• 分子量: 268.312
• InChiKey: RCWJSFCTMYHSCU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-Benzyloxy-7-methoxy-2H-chromene 在 2,3-二氯-5,6-二氰基-1,4-苯醌 、 lithium chloride 、 palladium dichloride 作用下， 以 四氢呋喃 、 丙酮 为溶剂， 反应 2.0h， 生成 2,8,9-Tris-benzyloxy-3-methoxy-benzo[4,5]furo[3,2-c]chromen-6-one
  参考文献：
  名称：

  Synthesis and preliminary pharmacological evaluation of coumestans with different patterns of oxygenation

  摘要：

  Five coumestans with different patterns of oxygenation in rings A and D were synthesized from resorcinol and aromatic aldehydes, and screened for their antimyotoxic activity. The most potent compound (2b, IC50= 1 muM) was selected for study of its pharmacological profile. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00621-1
• 作为产物：
  描述：

  4-苄氧基-3-甲氧基苯甲醛 在 盐酸 、 氢氧化钾 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 6-Benzyloxy-7-methoxy-2H-chromene
  参考文献：
  名称：

  Synthesis and preliminary pharmacological evaluation of coumestans with different patterns of oxygenation

  摘要：

  Five coumestans with different patterns of oxygenation in rings A and D were synthesized from resorcinol and aromatic aldehydes, and screened for their antimyotoxic activity. The most potent compound (2b, IC50= 1 muM) was selected for study of its pharmacological profile. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00621-1

文献信息

• Synthesis and preliminary pharmacological evaluation of coumestans with different patterns of oxygenation
  作者：Alcides J.M da Silva、Paulo A Melo、Noelson M.V Silva、Flávia V Brito、Camilla D Buarque、Daniele V de Souza、Verônica P Rodrigues、Elisa S.C Poças、François Noël、Edson X Albuquerque、Paulo R.R Costa

  DOI：10.1016/s0960-894x(00)00621-1

  日期：2001.2

  Five coumestans with different patterns of oxygenation in rings A and D were synthesized from resorcinol and aromatic aldehydes, and screened for their antimyotoxic activity. The most potent compound (2b, IC50= 1 muM) was selected for study of its pharmacological profile. (C) 2001 Elsevier Science Ltd. All rights reserved.