6-[(4-bromophenyl)methylsulfanyl]-3-(pyridin-3-ylmethyl)-2,4-dihydro-1H-1,3,5-triazine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-[(4-bromophenyl)methylsulfanyl]-3-(pyridin-3-ylmethyl)-2,4-dihydro-1H-1,3,5-triazine
• 化学式: C₁₆H₁₇BrN₄S
• 分子量: 377.3
• InChiKey: QGARWQFYOMNBPJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  65.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• AUTOPHAGY INHIBITORS
  申请人：Deutsches Krebsforschungszentrum

  公开号：EP3184514A1

  公开（公告）日：2017-06-28

  A compound, which is a) a tetrahydrotriazine derivative of the formula (I), a tautomer, a pharmaceutically acceptable salt, a solvate or hydrate thereof, were the symbols have the meanings given in the description, or b) a coumarin derivative of the formula (II), a tautomer, a pharmaceutically acceptable salt, solvate or hydrate thereof, were the symbols have the meanings given in the description, is useful in a therapeutical method for inhibiting autophagy in a cell and for the treatment of cancer.

  一种化合物，其为 a) 公式（I）的四氢三唑衍生物， 其互变体，药学上可接受的盐，溶剂合物或水合物，其中符号的含义如描述中所给， 或者 b) 公式（II）的香豆素衍生物， 其互变体，药学上可接受的盐，溶剂合物或水合物，其中符号的含义如描述中所给， 在细胞中抑制自噬并用于癌症治疗的治疗方法中是有用的。
• ACYLATION OF BIOPOLYMER COMPRISING ANHYDROGLUCOSE UNITS
  申请人：SAPPI Netherlands Services B.V.

  公开号：EP3184549A1

  公开（公告）日：2017-06-28

  A process for the preparation of particulate acylated biopolymer comprising anhydroglucose units, said process comprising the steps of a. dispersing an amount of particulate non-surface modified biopolymer comprising anhydroglucose units in an amount of a liquid alkenyl carboxylate, or of a mixture of two or more liquid alkenyl carboxylates, in order to form a first dispersion, b. adding a catalytic composition to the first dispersion such a to form a second dispersion, c. heating the second dispersion to a temperature above ambient temperature d. cooling the second dispersion to ambient temperature, e. isolating the obtained particulate acylated biopolymer, wherein the amount of a liquid alkenyl carboxylate, or a mixture of two or more liquid alkenyl carboxylates, corresponds to a molar excess of alkenyl carboxylate, the molar excess being defined with respect to the moles of anhydroglucose units comprised in the amount of the particulate non-surface modified biopolymer, and wherein the catalytic composition comprises an amount of one, or two or more, non-nucleophilic bases

  一种制备包含脱水葡萄糖单元的颗粒状酰化生物聚合物的工艺，所述工艺包括以下步骤 a. 将一定量的包含脱水葡萄糖单元的非表面改性生物聚合物分散在一定量的液态烯基羧酸酯或两种或两种以上液态烯基羧酸酯的混合物中，以形成第一分散液、 b. 在第一分散液中加入催化成分，以形成第二分散液、 c. 将第二分散液加热到高于环境温度的温度 d. 将第二分散液冷却至环境温度 e. 分离得到的颗粒状酰化生物聚合物、 其中液态烯基羧酸酯或两种或两种以上液态烯基羧酸酯的混合物的量相当于烯基羧酸酯的摩尔过量，摩尔过量的定义是相对于颗粒状非表面改性生物聚合物中包含的脱水葡萄糖单元的摩尔数，其中催化组合物包含一种或两种或两种以上非亲核碱的量
• [EN] ANTIBACTERIAL AGENTS<br/>[FR] AGENTS ANTIBACTÉRIENS
  申请人：UNIV MCMASTER

  公开号：WO2008025152A1

  公开（公告）日：2008-03-06

  [EN] A novel class of antibiotics that interfere with lipoprotein targeting have been identified. A high gene copy suppression method is used to identify new compounds. Novel compositions containing the antimicrobials are disclosed as well as their uses.
  [FR] L'invention concerne l'identification d'une nouvelle classe d'antibiotiques qui interfèrent avec le ciblage de lipoprotéines. Un procédé de forte suppression de copies de gène est utilisé afin d'identifier de nouveaux composés. L'invention concerne également de nouvelles compositions contenant ces agents antimicrobiens, ainsi que leurs utilisations.