5-Chloro-2-(((4-chloro-3-nitrophenyl)sulfonyl)amino)-N-(4-chlorophenyl)benzamide | 136402-17-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-Chloro-2-(((4-chloro-3-nitrophenyl)sulfonyl)amino)-N-(4-chlorophenyl)benzamide
• 英文别名: 5-chloro-2-[(4-chloro-3-nitrophenyl)sulfonylamino]-N-(4-chlorophenyl)benzamide
• CAS: 136402-17-0
• 化学式: C19H12Cl3N3O5S
• mdl: MFCD00552788
• 分子量: 500.7
• InChiKey: BFXLAXBXCXOWNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  130
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• METHODS FOR TREATMENT OF MICROCEPHALY ASSOCIATED AUTISM DISORDERS
  申请人：BROWN UNIVERSITY

  公开号：US20160193296A1

  公开（公告）日：2016-07-07

  The invention features methods for the treatment of one or more symptoms of microcephaly associated autism disorders e.g., Christianson syndrome, by administering agents that increase the level or activity of BDNF or TrkB in the brain of the patient. These agents may include BDNF, a BDNF agonist, a BDNF mimetic, a TrkB agonist, a cell expressing recombinant BDNF, a BDNF encoding recombinant nucleic acid molecule encapsidated within a recombinant virus, and an agent that decreases the acidity of endosomes.
• COMPOSITIONS AND METHODS FOR ENHANCING GENOME EDITING
  申请人：The Regents of the University of California

  公开号：US20200115688A1

  公开（公告）日：2020-04-16

  The present disclosure provides a composition comprising an RNA-guided endonuclease and an agent that decreases the acidity of an endosome. The present disclosure provides a composition comprising: a) a ribonucleoprotein (RNP) complex comprising: i) an RNA-guided endonuclease; and ii) a guide RNA comprising a segment that binds to the RNA-guided endonuclease and a segment that binds to a target nucleic acid; and b) an agent that decreases the acidity of an endosome. The present disclosure provides methods of binding a target nucleic acid in a eukaryotic cell; and methods of genetically modifying a target eukaryotic cell.
• [EN] COMPOSITIONS AND METHODS FOR ENHANCING GENOME EDITING<br/>[FR] COMPOSITIONS ET PROCÉDÉS D'AMÉLIORATION DE CORRECTION DE SÉQUENCE GÉNOMIQUE
  申请人：UNIV CALIFORNIA

  公开号：WO2019036185A1

  公开（公告）日：2019-02-21

  The present disclosure provides a composition comprising an RNA-guided endonuclease and an agent that decreases the acidity of an endosome. The present disclosure provides a composition comprising: a) a ribonucleoprotein (RNP) complex comprising: i) an RNA-guided endonuclease; and ii) a guide RNA comprising a segment that binds to the RNA-guided endonuclease and a segment that binds to a target nucleic acid; and b) an agent that decreases the acidity of an endosome. The present disclosure provides methods of binding a target nucleic acid in a eukaryotic cell; and methods of genetically modifying a target eukaryotic cell.