N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]adamantane-1-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]adamantane-1-carboxamide
• 化学式: C₂₀H₂₃N₃O₃S₂
• 分子量: 417.5
• InChiKey: HKCNYVCUTWNVBI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  125
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Compositions Useful as Inhibitors of Voltage-Gated Sodium Channels
  申请人：Vertex Pharmaceuticals Incorporated

  公开号：US20130184258A1

  公开（公告）日：2013-07-18

  The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

  本发明涉及一种作为电压门控钠通道抑制剂有用的化合物。本发明还提供了包含本发明化合物的药学上可接受的组合物，并且提供了使用这些组合物治疗各种疾病的方法。
• Adamantane or pinene derivatives for use in the treatment of chlamydiales infections
  申请人：Commissariat a l'Energie Atomique et aux Energies Alternatives

  公开号：US10039727B2

  公开（公告）日：2018-08-07

  The present invention relates to a method for treating a Chlamydiales infection comprising the administration of a therapeutically effective amount of a compound of formula (I) to a subject in need thereof: W-L1-NH-L2-Ar   (I) Wherein W, L1, L2 and Ar are as defined in claim 1.

  本发明涉及一种治疗衣原体感染的方法，包括向有需要的受试者施用治疗有效量的式（I）化合物： W-L1-NH-L2-Ar (I) 其中 W、L1、L2 和 Ar 如权利要求 1 所定义。
• ADAMANTANE OR PINENE DERIVATIVES FOR USE IN THE TREATMENT OF CHLAMYDIALES INFECTIONS
  申请人：COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES

  公开号：EP3085688B1

  公开（公告）日：2020-08-19
• Adamantane or Pinene Derivatives for Use in the Treatment of Chlamydiales Infections
  申请人：Commissariat a l'Energie Atomique et aux Energies Alternatives

  公开号：US20160310448A1

  公开（公告）日：2016-10-27

  The present invention relates to a method for treating a Chlamydiales infection comprising the administration of a therapeutically effective amount of a compound of formula (I) to a subject in need thereof: W—L 1 —NH—L 2 —Ar  (I) Wherein W, L1, L2 and Ar are as defined in claim 1.