5-{[(3-Amino-4-chlorophenyl)sulfonyl]amino}benzene-1,3-dicarboxylic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-{[(3-Amino-4-chlorophenyl)sulfonyl]amino}benzene-1,3-dicarboxylic acid
• 英文别名: 5-[(3-amino-4-chlorophenyl)sulfonylamino]benzene-1,3-dicarboxylic acid
• 化学式: C₁₄H₁₁ClN₂O₆S
• 分子量: 370.8
• InChiKey: JYSOXSKGHTYTRW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  155
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  5-[(4-Chloro-3-nitrophenyl)sulfonylamino]benzene-1,3-dicarboxylic acid 、 水 生成 5-{[(3-Amino-4-chlorophenyl)sulfonyl]amino}benzene-1,3-dicarboxylic acid
  参考文献：
  名称：

  BLUS, KAZMIERZ;KRASKA, JAN, DYES AND PIGM., 13,(1990) N, C. 233-240

  摘要：

  DOI：

文献信息

• Screening Method and Compounds for Modulating Telomerase Activity
  申请人：Skordalakes Emmanuel

  公开号：US20120309759A1

  公开（公告）日：2012-12-06

  The present invention embraces methods for identifying compounds that modulate the activity of telomerase. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the TRBD, “thumb,” “finger,” and/or “palm” domain; or FP-pocket, PT-pocket or Th-pocket of telomerase and testing the compound for its ability to modulate the activity of telomerase. Compounds selected for interacting with the T-pocket or Fingers-Palm pocket of telomerase are also provided.
• US9234230B2
  申请人：——

  公开号：US9234230B2

  公开（公告）日：2016-01-12
• [EN] SCREENING METHOD AND COMPOUNDS FOR MODULATING TELOMERASE ACTIVITY<br/>[FR] PROCEDE DE CRIBLAGE ET COMPOSES POUR MODULER L'ACTIVITE DE LA TELOMERASE
  申请人：WISTAR INST

  公开号：WO2011097600A1

  公开（公告）日：2011-08-11

  The present invention embraces methods for identifying compounds that modulate the activity of telomerase. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the TRBD, "thumb," "finger," and/or "palm" domain; or FP-pocket, PT-pocket or Th-pocket of telomerase and testing the compound for its ability to modulate the activity of telomerase. Compounds selected for interacting with the T-pocket or Fingers-Palm pocket of telomerase are also provided.