N-(7-(1-(4-chloro-2-methylphenoxy)ethyl)-6-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-N'-hydroxy-formamidine | 1246298-76-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三唑并嘧啶类
• 英文名称: N-(7-(1-(4-chloro-2-methylphenoxy)ethyl)-6-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-N'-hydroxy-formamidine
• 英文别名: N'-[7-[1-(4-chloro-2-methylphenoxy)ethyl]-6-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]-N-hydroxymethanimidamide
• CAS: 1246298-76-9
• 化学式: C₁₆H₁₇ClN₆O₂
• 分子量: 360.803
• InChiKey: ZPGONMWFLIRUJE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  96.9
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• SUBSTITUTED [1,2,4]TRIAZOLO[1,5-a]PYRIMIDINES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS
  申请人：Sørensen Ulrik Svane

  公开号：US20120101112A1

  公开（公告）日：2012-04-26

  This invention relates to novel substituted [1,2,4]triazolo[1,5-a]pyrimidines and their use as modulators of potassium channels. In other aspects the invention relates to the use of these compounds, in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.