3-(4-Methoxy-benzylamino)-1-phenyl-pyrrolidine-2,5-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 3-(4-Methoxy-benzylamino)-1-phenyl-pyrrolidine-2,5-dione
• 英文别名: 3-[(4-Methoxybenzyl)amino]-1-phenylpyrrolidine-2,5-dione；3-[(4-methoxyphenyl)methylamino]-1-phenylpyrrolidine-2,5-dione
• 化学式: C₁₈H₁₈N₂O₃
• 分子量: 310.353
• InChiKey: KBCFFMDJDDBDJN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-苯基马来酰亚胺 、 4-甲氧基苄胺 在 四甲基乙二胺 作用下， 以 氘代氯仿 为溶剂， 反应 24.0h， 生成 (E)-But-2-enedioic acid 4-methoxy-benzylamide phenylamide 、 3-(4-Methoxy-benzylamino)-1-phenyl-pyrrolidine-2,5-dione
  参考文献：
  名称：

  Chemoselective, accelerated and stereoselective aza-Michael addition of amines to N-phenylmaleimide by using TMEDA based receptors

  摘要：

  An aza-Michael addition between a maleimide and amines is described in which the presence of simple amine receptors (TMEDA or trans-TMCDA) promote the chemo selectivity of the reaction (respectively, 1,2- and 1,4-addition). Additionally, both receptors are able to accelerate the reaction. Stoichiometries of complexes between receptors and amines were determined by H-1 NMR dilution experiments while enantiomeric excesses were observed on 1,4-adducts by using (1R,2R)-TMCDA. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2004.10.006