3-Fluoro-4-oxo-3-phenylbutanamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-Fluoro-4-oxo-3-phenylbutanamide
• 英文别名: 3-fluoro-4-oxo-3-phenylbutanamide
• 化学式: C₁₀H₁₀FNO₂
• 分子量: 195.19
• InChiKey: VFFKDCMJDWYAFE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  60.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] DEUTERATED FELBAMATE, COMPOSITIONS CONTAINING THE SAME, AND METHODS OF USE THEREOF<br/>[FR] FELBAMATE DEUTÉRÉ, SES COMPOSITIONS ET SES PROCÉDÉS D'UTILISATION
  申请人：PEROSPHERE INC

  公开号：WO2015100252A1

  公开（公告）日：2015-07-02

  Felbamate deuterated at the 2 position, compositions containing the same, and methods of making and using thereof are described herein. Substitution of the hydrogen at the 2 position with deuterium should prevent or reduce formation of the toxic metabolite atropaldehyde (ATPAL), which is the cause of felbamate toxicity. The deuterated felbamate can be administered enterally (e.g., orally) or parenterally (e.g., by injection) to treat a variety of neurological diseases or disorders. Suitable daily dosages of the active agent are 100-2000 mg, preferably 200-1000 mg, more preferably 400-600 mg.