1-Benzhydryl-3-(2-phenoxy-acetyl)-urea | 60758-34-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Benzhydryl-3-(2-phenoxy-acetyl)-urea
• 英文别名: N-(benzhydrylcarbamoyl)-2-phenoxyacetamide
• CAS: 60758-34-1
• 化学式: C₂₂H₂₀N₂O₃
• 分子量: 360.412
• InChiKey: OHWCDNAMELYHQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  67.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-二苯甲基脲 、 苯氧乙酰氯 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 以89%的产率得到1-Benzhydryl-3-(2-phenoxy-acetyl)-urea
  参考文献：
  名称：

  Solid-Phase Synthesis of Disubstituted N-Acylureas from Resin-Bound Ureas and Acyl Chlorides

  摘要：

  Acylureas (ureides) are valued for their important biological activities. Whereas cyclic acylureas have frequently been the object of solid-phase chemistry, only few reports have focused on the solid-supported preparation of acyclic representatives. We have prepared different types of acylureas on Rink amide resin in three or four steps. The products are either N-acylated (9, 18), N-acylated-N'-allcylated (10, 19), or N-acylated-N-alkylated (22). Characteristic NMR parameters of isomeric acylureas 10, 19, and 22 are discussed.

  DOI：

  10.1021/co100020b

文献信息

• Solid-Phase Synthesis of Disubstituted <i>N</i>-Acylureas from Resin-Bound Ureas and Acyl Chlorides
  作者：Hans-Georg Häcker、Manuela Meusel、Melanie Aschfalk、Michael Gütschow

  DOI：10.1021/co100020b

  日期：2011.1.10

  Acylureas (ureides) are valued for their important biological activities. Whereas cyclic acylureas have frequently been the object of solid-phase chemistry, only few reports have focused on the solid-supported preparation of acyclic representatives. We have prepared different types of acylureas on Rink amide resin in three or four steps. The products are either N-acylated (9, 18), N-acylated-N'-allcylated (10, 19), or N-acylated-N-alkylated (22). Characteristic NMR parameters of isomeric acylureas 10, 19, and 22 are discussed.