1-Ethyl-2-(trifluoromethyl)cyclopropane

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氟化物
• 英文名称: 1-Ethyl-2-(trifluoromethyl)cyclopropane
• 英文别名: 1-ethyl-2-(trifluoromethyl)cyclopropane
• 化学式: C₆H₉F₃
• 分子量: 138.13
• InChiKey: VDSGPHVDYQWIHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• HETEROCYCLIC COMPOUND
  申请人：Sumitomo Chemical Company, Limited

  公开号：US20190040038A1

  公开（公告）日：2019-02-07

  A compound represented by formula (I) or an N-oxide compound thereof is provided with excellent control efficacies against harmful arthropods, wherein A 1 represents a nitrogen atom or a CR 4 ; R 4 represents a hydrogen atom, a OR 27 , a NR 27 R 28 , a cyano group, a nitro group, or a halogen atom; hereinafter referred to as “Het”, represents Het-1, Het-2, Het-3, or Het-4: wherein # 1 represents the binding position of Het and T, and # 2 represents the binding position of Het and T represents T-1, T-2, T-3, T-4, T-5, T-6, or T-7: R 1 represents a C1-C10 chain hydrocarbon group having one or more halogen atoms or the like; and R 2 represents a C1-C6 alkyl group optionally having one or more halogen atoms or the like.

  提供了由化学式（I）表示的化合物或其N-氧化物，对有害节肢动物具有出色的控制效果，其中A1表示氮原子或CR4；R4表示氢原子、OR27、NR27R28、氰基、硝基或卤素原子；下文中所称的“Het”表示Het-1、Het-2、Het-3或Het-4：其中#1表示Het和T的结合位置，#2表示Het和T的结合位置，T表示T-1、T-2、T-3、T-4、T-5、T-6或T-7：R1表示具有一个或多个卤素原子的C1-C10链烃基；R2表示可选地具有一个或多个卤素原子的C1-C6烷基基团。
• [EN] lSOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF<br/>[FR] DÉRIVÉS D'ISOXAZOLE UTILISÉS COMME AGONISTES DE FXR ET LEURS MÉTHODES D'UTILISATION
  申请人：ENANTA PHARM INC

  公开号：WO2017201155A1

  公开（公告）日：2017-11-23

  The present invention provides compounds of Formula I: (I) and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising these compounds and methods of using these compounds to treat or prevent a disease or disorder mediated by FXR. Specifically, the present invention relates to isoxazole derivatives useful as agonists for FXR and methods for their preparation and use.

  本发明提供了式I的化合物：（I）及其药学上可接受的盐、包含这些化合物的制药组合物以及使用这些化合物治疗或预防由FXR介导的疾病或疾病的方法。具体而言，本发明涉及作为FXR激动剂有用的异恶唑衍生物及其制备和使用方法。
• Bipyridine compound and use of same for noxious arthropod control
  申请人：Sumitomo Chemical Company, Limited

  公开号：US10172356B2

  公开（公告）日：2019-01-08

  A bipyridine compound having an excellent controlling effect against noxious arthropods is provided. In particular, a bipyridine compound of formula (I) or an N-oxide thereof is provided in which the variable groups are as described in the specification. Also provided are compositions containing the bipyridine compound or an N-oxide thereof, and methods of using such compounds and compositions to control noxious arthropods.

  本发明提供了一种对有害节肢动物具有极佳防治效果的双吡啶化合物。特别是提供了一种式（I）的联吡啶化合物或其 N-氧化物，其中的可变基团如说明书所述。此外，还提供了含有双吡啶化合物或其 N-氧化物的组合物，以及使用这种化合物和组合物防治有害节肢动物的方法。
• Pyridine compound
  申请人：Sumitomo Chemical Company, Limited

  公开号：US10273210B2

  公开（公告）日：2019-04-30

  A pyridine compound represented by formula (I), or an N-oxide thereof is provided, wherein the variable groups are as defined in the specification. The pyridine compound of formula has excellent control effects against harmful arthropods.

  本发明提供了一种由式（I）代表的吡啶化合物或其 N-氧化物，其中的可变基团如说明书中所定义。式中的吡啶化合物对有害节肢动物有很好的防治效果。
• Pyrazine compound and arthropod pest control agent containing same
  申请人：Sumitomo Chemical Company, Limited

  公开号：US10577343B2

  公开（公告）日：2020-03-03

  Provided is a compound represented by formula (I): or an N-oxide compound thereof, wherein the variable groups are as defined in the specification. Also provided is an arthropod pest control agent containing a compound represented by formula (I) and an inert carrier. The compound represented by formula (I) and arthropod pest control agent exhibit an excellent controlling effect against arthropod pests.

  本文提供了一种由式 (I) 表示的化合物： 或其 N-氧化物化合物，其中可变基团如说明书中所定义。还提供了一种节肢动物害虫防治剂，含有式（I）代表的化合物和惰性载体。式 (I) 所代表的化合物和节肢动物害虫防治剂对节肢动物害虫有很好的防治效果。