1-Ethyl-2-fluorocyclobutane

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氟化物
• 英文名称: 1-Ethyl-2-fluorocyclobutane
• 英文别名: 1-ethyl-2-fluorocyclobutane
• 化学式: C₆H₁₁F
• 分子量: 102.15
• InChiKey: QBIFTGCRGGWBGX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  7
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] STAT INHIBITORY COMPOUNDS AND COMPOSITIONS<br/>[FR] COMPOSÉS ET COMPOSITIONS INHIBITEURS DE STAT
  申请人：JANPIX LTD

  公开号：WO2021178907A1

  公开（公告）日：2021-09-10

  Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for the inhibition of Signal Transducer and Activator of Transcription 5a and 5b (STAT5). Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as, for example, breast cancer and pancreatic cancer.

  提供的是化合物和包含这些化合物的药物组合物，它们对于抑制信号转导子和转录激活子5a和5b（STAT5）有益。此外，这些主题化合物和组合物对于治疗癌症，例如乳腺癌和胰腺癌，是有用的。
• [EN] ALPHA SUBSTITUTED STAT INHIBITORS AND COMPOSITIONS THEREOF<br/>[FR] INHIBITEURS DE STAT À SUBSTITUTION ALPHA ET COMPOSITIONS DE CEUX-CI
  申请人：JANPIX LTD

  公开号：WO2021178857A1

  公开（公告）日：2021-09-10

  Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for the inhibition of Signal Transducer and Activator of Transcription 5a and 5b (STAT5). Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as, for example, breast cancer and pancreatic cancer.

  本文提供了一些化合物和含有这些化合物的药物组合物，可用于抑制信号转导和激活转录因子5a和5b（STAT5）。此外，这些化合物和组合物可用于治疗癌症，例如乳腺癌和胰腺癌。
• [EN] BIFUNCTIONAL COMPOUNDS FOR DEGRADATION OF EGFR AND RELATED METHODS OF USE<br/>[FR] COMPOSÉS BIFONCTIONNELS POUR LA DÉGRADATION DE L'EGFR ET PROCÉDÉS D'UTILISATION ASSOCIÉS
  申请人：BEIGENE LTD

  公开号：WO2022068849A1

  公开（公告）日：2022-04-07

  Disclosed herein are bifunctional compounds formed by conjugating EGFR inhibitor moieties with E3 ligase Ligand moieties, which function to recruit targeted proteins to E3 ubiquitin ligase for degradation of mutant EGFR kinase, and methods of preparation and uses thereof.

  本文披露了一种双功能化合物，由EGFR抑制剂部分与E3连接配体部分结合而成，其功能是将靶向蛋白质招募到E3泛素连接酶降解突变EGFR激酶，并提供了其制备方法和用途。
• IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17
  申请人：Janssen Biotech, Inc.

  公开号：US20220402922A1

  公开（公告）日：2022-12-22

  The present application discloses compounds having the following formula: or pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 , R 4 and R 5 are defined in the specification, as well as methods of making and using the compounds disclosed herein for treating or ameliorating an IL-17 mediated syndrome, disorder and/or disease.