2-(3-Azidopropyl)benzaldehyde

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(3-Azidopropyl)benzaldehyde
• 英文别名: 2-(3-azidopropyl)benzaldehyde
• 化学式: C10H11N3O
• 分子量: 189.21
• InChiKey: VUBUVQIKYMGKAU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  31.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Microgel particles for the delivery of bioactive materials
  申请人：——

  公开号：US20030211158A1

  公开（公告）日：2003-11-13

  Novel microgels, microparticles and related polymeric materials capable of delivering bioactive materials to cells for use as vaccines or therapeutic agents. The materials are made using a crosslinker molecule that contains a linkage cleavable under mild acidic conditions. The crosslinker molecule is exemplified by a bisacryloyl acetal crosslinker. The new materials have the common characteristic of being able to degrade by acid hydrolysis under conditions commonly found within the endosomal or lysosomal compartments of cells thereby releasing their payload within the cell. The materials can also be used for the delivery of therapeutics to the acidic regions of tumors and sites of inflammation.

  新型微凝胶、微粒子和相关聚合物材料，能够传递生物活性物质到细胞，用作疫苗或治疗剂。这些材料使用一种含有在温和酸性条件下可断裂的连接剂分子制成。这种交联剂分子的例子是双丙烯酰基缩醛交联剂。新材料的共同特点是能够在细胞内体液泡或溶酶体内常见的条件下通过酸水解降解，从而在细胞内释放它们的有效载荷。这些材料还可以用于将治疗剂传递到肿瘤和炎症部位的酸性区域。
• MICROGEL PARTICLES FOR THE DELIVERY OF BIOACTIVE MATERIALS
  申请人：The Regents of the University of California

  公开号：EP1490083A1

  公开（公告）日：2004-12-29
• US7056901B2
  申请人：——

  公开号：US7056901B2

  公开（公告）日：2006-06-06
• US7683041B2
  申请人：——

  公开号：US7683041B2

  公开（公告）日：2010-03-23
• [EN] MICROGEL PARTICLES FOR THE DELIVERY OF BIOACTIVE MATERIALS<br/>[FR] PARTICULES DE MICROGEL POUR L'ADMINISTRATION DE MATIERES BIOACTIVES
  申请人：UNIV CALIFORNIA

  公开号：WO2003082316A1

  公开（公告）日：2003-10-09

  Novel microgels, microparticles and related polymeric materials capable of delivering bioactive materials to cells for use as vaccines or therapeutic agents. The materials are made using a crosslinker molecule that contains a linkage cleavable under mild acidic conditions. The crosslinker molecule is exemplified by a bisacryloyl acetal crosslinker. The new materials have the common characteristic of being able to degrade by acid hydrolysis under conditions commonly found within the endosomal or lysosomal compartments of cells thereby releasing their payload within the cell. The materials can also be used for the delivery of therapeutics to the acidic regions of tumors and sites of inflammation.