3-phenyl-propionic acid isopentylamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-phenyl-propionic acid isopentylamide
• 英文别名: 3-Phenyl-propionsaeure-isopentylamid；Propanamide, 3-phenyl-N-(3-methylbutyl)-；N-(3-methylbutyl)-3-phenylpropanamide
• 化学式: C₁₄H₂₁NO
• mdl: MFCD02860780
• 分子量: 219.327
• InChiKey: WDMXQGZXTKPLGF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  异戊胺 、 3-苯丙酰氯 在 苯 作用下， 生成 3-phenyl-propionic acid isopentylamide
  参考文献：
  名称：

  Kanao; Inagawa, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1938, vol. 58, p. 261,263; dtsch. Ref. S. 65

  摘要：

  DOI：

文献信息

• [EN] SMALL MOLECULE LEPTIN RECEPTOR MODULATORS<br/>[FR] MODULATEURS À PETITES MOLÉCULES DES RÉCEPTEURS DE LA LEPTINE
  申请人：BIOVITRUM AB PUBL

  公开号：WO2009147221A1

  公开（公告）日：2009-12-10

  The present invention relates to new compounds of formula (I), to pharmaceutical compositions comprising these compounds and to the use of these compounds as leptin receptor modulator mimetics in the preparation of medicaments against conditions associated with weight gain, type 2 diabetes and dyslipidemias.

  本发明涉及式(I)的新化合物，包含这些化合物的药物组合物，以及将这些化合物用作瘦素受体调节剂模拟物，用于制备治疗与体重增加、2型糖尿病和血脂异常相关的药物的用途。
• HETEROCYCLIC DERIVATIVES AS OREXIN ANTAGONISTS
  申请人：Gobbi Luca

  公开号：US20080249125A1

  公开（公告）日：2008-10-09

  The present invention relates to compounds of formula wherein R 1 , R 2 , R 3 , and R 4 are as defined herein and hetaryl is a one or two ring-membered heteroaromatic ring system, connected to the carbon atoms of the piperidine group selected from the group consisting of or to pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. These compounds are orexin receptor antagonists and may be useful in the treatment of disorders in which orexin pathways are involved, like sleep disorders.

  本发明涉及以下式中的化合物，其中R1、R2、R3和R4如本文所定义，而hetaryl是一个或两个环成员的杂芳环系统，连接到从以下群中选择的哌啶基的碳原子，或者是药用适宜的酸盐、光学纯对映体、拉克酸盐或二对映异构体混合物。这些化合物是促进睡眠受体拮抗剂，可能在涉及促进睡眠途径的疾病治疗中有用，如睡眠障碍。
• NOVEL COMPOUNDS AND USES
  申请人：The University of Queensland

  公开号：US20200207780A1

  公开（公告）日：2020-07-02

  The present invention relates to compounds of formula (I): wherein Q is O or S; R 1 is a cyclic group substituted with at least one group X, wherein R 1 may optionally be further substituted; X is any group comprising a carbonyl group; and R 2 is a cyclic group substituted at the α-position, wherein R 2 may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the dual action of NLRP 3 inhibition and the stimulation of insulin secretion.
• US8067598B2
  申请人：——

  公开号：US8067598B2

  公开（公告）日：2011-11-29