2-Thiomorpholin-4-ylmethyl-phenylamine | 237432-14-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Thiomorpholin-4-ylmethyl-phenylamine
• 英文别名: 2-(Thiomorpholin-4-ylmethyl)aniline
• CAS: 237432-14-3
• 化学式: C₁₁H₁₆N₂S
• mdl: MFCD11172062
• 分子量: 208.327
• InChiKey: ZAEZFXZNLSFHHF-UHFFFAOYSA-N

物化性质

• 沸点：
  354.8±37.0 °C(Predicted)
• 密度：
  1.173±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.454
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-Thiomorpholin-4-ylmethyl-phenylamine 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 反应 4.0h， 生成 Biphenyl-4-ylmethyl-(2-thiomorpholin-4-ylmethyl-phenyl)-amine
  参考文献：
  名称：

  Antimycobacterial activity of new ortho-, meta- and para-toluidine derivatives

  摘要：

  Novel toluidine derivatives are described. Some of them showed an interesting in vitro activity against Mycobacterium tuberculosis, M. smegmatis, M. marinum, M. gordonae, and M. avium. Some of them were more active than Streptomycin and Isoniazid, which were used as controls, against M. avium and M. gordonae. In particular, we confirm the good activity of biphenyl derivatives. (C) 1999 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(99)00084-1
• 作为产物：
  描述：

  2-硝基苄氯 在 盐酸 、 三乙胺 、 sodium iodide 、 tin(ll) chloride 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 7.0h， 生成 2-Thiomorpholin-4-ylmethyl-phenylamine
  参考文献：
  名称：

  Mai, Antonello; Sbardella, Gianluca; Artico, Marino, Medicinal Chemistry Research, 1999, vol. 9, # 3, p. 149 - 161

  摘要：

  DOI：

文献信息

• [EN] HETEROCYCLIC DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C<br/>[FR] DÉRIVÉS HÉTÉROCYCLIQUES ET LEUR UTILISATION DANS LE TRAITEMENT DE L'HÉPATITE C
  申请人：ARROW THERAPEUTICS LTD

  公开号：WO2009034390A1

  公开（公告）日：2009-03-19

  Use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in treating or alleviating HCV, formula (I): wherein R1, R2, R4, Y1, Y2, Y3, A, B and W are as defined in the specification.

  在制造用于治疗或缓解HCV的药物的过程中使用化合物(I)的一种，或其药学上可接受的盐，化合物(I)的结构如下：其中R1、R2、R4、Y1、Y2、Y3、A、B和W的定义如规范中所述。
• BENZOPYRROLIDONE DERIVATIVES POSSESSING ANTIVIRAL AND ANTICANCER PROPERTIES
  申请人：Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

  公开号：EP3056202A1

  公开（公告）日：2016-08-17

  The present invention relates to benzopyrrolidone derivatives and/or pharmaceutically acceptable salts thereof for the use in the treatment of infectious diseases or cancer, and pharmaceutical compositions containing at least one of said benzopyrrolidone derivatives and/or pharmaceutically acceptable salts thereof for the use in the treatment of infectious diseases or cancer.

  本发明涉及苯并吡咯烷酮衍生物和/或其药用可接受盐，用于治疗传染病或癌症，并包含至少一种所述苯并吡咯烷酮衍生物和/或其药用可接受盐的药物组合物，用于治疗传染病或癌症。
• Antimycobacterial activity of new ortho-, meta- and para-toluidine derivatives
  作者：Mariangela Biava、Rossella Fioravanti、Giulio Cesare Porretta、Giancarlo Sleiter、Delia Deidda、Giorgio Lampis、Raffaello Pompei

  DOI：10.1016/s0014-827x(99)00084-1

  日期：1999.11

  Novel toluidine derivatives are described. Some of them showed an interesting in vitro activity against Mycobacterium tuberculosis, M. smegmatis, M. marinum, M. gordonae, and M. avium. Some of them were more active than Streptomycin and Isoniazid, which were used as controls, against M. avium and M. gordonae. In particular, we confirm the good activity of biphenyl derivatives. (C) 1999 Elsevier Science S.A. All rights reserved.
• [EN] BENZOPYRROLIDONE DERIVATIVES POSSESSING ANTIVIRAL AND ANTICANCER PROPERTIES<br/>[FR] DÉRIVÉS DE BENZOPYRROLIDONE POSSÉDANT DES PROPRIÉTÉS ANTIVIRALES ET ANTICANCÉREUSES
  申请人：MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WSS E V

  公开号：WO2016131789A1

  公开（公告）日：2016-08-25

  The present invention relates to benzopyrrolidone derivatives and/or pharmaceutically acceptable salts thereof for the use in the treatment of infectious diseases or cancer, and pharmaceutical compositions containing at least one of said benzopyrrolidone derivatives and/or pharmaceutically acceptable salts thereof for the use in the treatment of infectious diseases or cancer.
• Mai, Antonello; Sbardella, Gianluca; Artico, Marino, Medicinal Chemistry Research, 1999, vol. 9, # 3, p. 149 - 161
  作者：Mai, Antonello、Sbardella, Gianluca、Artico, Marino、Massa, Silvio、Lampis, Giorgio、Deidda, Delia、Pompeit, Raffaello

  DOI：——

  日期：——