Cambridge id 6838807

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Cambridge id 6838807
• 英文别名: 2-chloro-N-(2-chloro-4-nitrophenyl)-4-methylbenzamide
• 化学式: C14H10Cl2N2O3
• 分子量: 325.1
• InChiKey: BATLAWZDEKQQKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  74.9
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• SALICYLANILIDE MODIFIED PEPTIDES FOR USE AS ORAL THERAPEUTICS
  申请人：Fogelman Alan M.

  公开号：US20110183889A1

  公开（公告）日：2011-07-28

  This invention pertains to the surprising discovery that salicylanilides, e.g., niclosamide and/or niclosamide analogues can be reacted with a therapeutically active peptide to produce a modified peptide complex that shows increased resistance to proteolysis and that shows higher bioactivity when orally administered than the unmodified peptide.
• [EN] SALICYLANILIDE MODIFIED PEPTIDES FOR USE AS ORAL THERAPEUTICS<br/>[FR] PEPTIDES MODIFIÉS PAR DES SALICYLANILIDES SERVANT DE SUBSTANCE THÉRAPEUTIQUE ORALE
  申请人：UNIV CALIFORNINA

  公开号：WO2009032749A2

  公开（公告）日：2009-03-12

  This invention pertains to the surprising discovery that salicylanilides, e.g., niclosamide and/or niclosamide analogues can be reacted with a therapeutically active peptide to produce a modified peptide complex that shows increased resistance to proteolysis and that shows higher bioactivity when orally administered than the unmodified peptide.