N-[4-[(3-methoxypyrazin-2-yl)sulfamoyl]phenyl]-3-(5-nitrothiophen-2-yl)prop-2-enamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[4-[(3-methoxypyrazin-2-yl)sulfamoyl]phenyl]-3-(5-nitrothiophen-2-yl)prop-2-enamide
• 化学式: C18H15N5O6S2
• 分子量: 461.5
• InChiKey: FNPPHVLYVGMZMZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  193
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• PREVENTION OF TUMOUR METASTASIS BY INHIBITION OF NECROPTOSIS
  申请人：Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

  公开号：EP3180014A1

  公开（公告）日：2017-06-21
• COMPOSITIONS FOR CRYOPRESERVATION AND METHODS OF USE THEREOF
  申请人：Evergreen Biosciences

  公开号：EP3731841A1

  公开（公告）日：2020-11-04
• [EN] PREVENTION OF TUMOUR METASTASIS BY INHIBITION OF NECROPTOSIS<br/>[FR] PRÉVENTION DES MÉTASTASES TUMORALES PAR INHIBITION DE LA NÉCROPTOSE
  申请人：MAX PLANCK GES ZUR FÖRDERUNG DER WISSENSCHAFTEN E V

  公开号：WO2016023918A1

  公开（公告）日：2016-02-18

  The present invention relates to an inhibitor of necroptosis for use in preventing the metastasis of tumours. Further, the present invention relates to a method of preventing the metastasis of tumours by inhibiting necroptosis and to a method for modulating the transmigration of metastasising tumour cells through endothelium by modulating necroptosis as well as to an in-vitro method of identifying an inhibitor of necroptosis suitable as a lead compound and/or as a medicament for the prevention of tumour metastasis. Moreover, the present invention also relates to a method of identifying necroptotic and necrotic cells.