2,4-dichloro-N-{4-[(1,3,3-trimethyl-6-azabicyclo[3.2.1]oct-6-yl)carbonyl]phenyl}benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4-dichloro-N-{4-[(1,3,3-trimethyl-6-azabicyclo[3.2.1]oct-6-yl)carbonyl]phenyl}benzamide
• 英文别名: 2,4-dichloro-N-[4-(1,3,3-trimethyl-6-azabicyclo[3.2.1]octane-6-carbonyl)phenyl]benzamide
• 化学式: C₂₄H₂₆Cl₂N₂O₂
• mdl: MFCD01896065
• 分子量: 445.4
• InChiKey: UNFFTTLFOJCQPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  30
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• 11beta-hydroxysteroid dehydrogenase type 1 active compounds
  申请人：Gundertofte Anette

  公开号：US20060089349A1

  公开（公告）日：2006-04-27

  A novel class of compounds of the general formula (I), their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are described. The present compounds modulate the activity of 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) and are accordingly useful in the treatment of diseases in which such a modulation is beneficial, e.g. the metabolic syndrome.

  本文描述了一类新的化合物，其一般式为(I)，以及它们在治疗中的用途、包含这些化合物的制药组合物，以及它们在制药中的用途。这些化合物调节11β-羟甾酮脱氢酶1型（11βHSD1）的活性，因此在治疗需要这种调节有益的疾病，如代谢综合症方面具有用途。
• 11Beta-Hydroxysteroid Dehydrogenase Type 1 Active Compounds
  申请人：Gundertofte Anette

  公开号：US20100120743A1

  公开（公告）日：2010-05-13

  A novel class of compounds of the general formula (I), their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are described. The present compounds modulate the activity of 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) and are accordingly useful in the treatment of diseases in which such a modulation is beneficial, e.g. the metabolic syndrome.

  本文介绍了一类新型化合物，其通用式为（I），以及它们在治疗中的应用，包括含有这些化合物的制药组合物，以及它们在药物制剂制备中的应用。这些化合物可调节11β-羟基类固醇脱氢酶1型（11βHSD1）的活性，因此可用于治疗需要这种调节有益的疾病，例如代谢综合征。
• 11Beta-Hydroxysteroid dehydrogenase type 1 active compounds
  申请人：NOVO NORDISK A/S

  公开号：EP1787982A2

  公开（公告）日：2007-05-23

  A novel class of compounds of the general formula (I), their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are described. The present compounds modulate the activity of 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) and are accordingly useful in the treatment of diseases in which such a modulation is beneficial, e.g. the metabolic syndrome.

  本文描述了通式（I）的一类新型化合物、它们在治疗中的用途、包含这些化合物的药物组合物以及它们在制造药物中的用途。本化合物可调节 11β- 羟基类固醇脱氢酶 1 型（11βHSD1）的活性，因此可用于治疗这种调节有益的疾病，如代谢综合征。
• EP1618090A1
  申请人：——

  公开号：EP1618090A1

  公开（公告）日：2006-01-25
• US7700583B2
  申请人：——

  公开号：US7700583B2

  公开（公告）日：2010-04-20