6-phenylthian-3-one | 86869-79-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻烷
• 英文名称: 6-phenylthian-3-one
• 英文别名: 6-Phenyl-1-thian-3-one
• CAS: 86869-79-6
• 化学式: C₁₁H₁₂OS
• 分子量: 192.282
• InChiKey: GYYHFMUKAYURTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  42.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  petivericin 、 2-ethoxy-buta-1,3-diene 、 甲苯 生成 6-phenylthian-3-one
  参考文献：
  名称：

  BALDWIN, J. E.;LOPEZ, R. C. G., TETRAHEDRON, 1983, 39, N 9, 1487-1498

  摘要：

  DOI：

文献信息

• Addition reactions of some simple thioaldehydes
  作者：Jack E. Baldwin、R.C.Gerald Lopez

  DOI：10.1016/s0040-4020(01)88553-7

  日期：1983.1

  When generated at 100°C, aliphatic and aromatic thioaldehydes without electronic bias are shown to undergo addition reactions to both aliphatic and aromatic 1,3-dienes. The reaction is shown to have application in an intramolecular example.

  当在100°C下生成时，无电子偏压的脂族和芳族硫醛显示出会同时发生脂族和芳族1,3-二烯加成反应。该反应显示出在分子内实例中的应用。
• HETEROCYCLIC COMPOUNDS AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES
  申请人：Biftu Tesfaye

  公开号：US20110224195A1

  公开（公告）日：2011-09-15

  The present invention is directed to substituted six-membered heterocyclic compounds of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as obesity and diabetes, particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

  本发明涉及结构式（I）的取代六元杂环化合物，它们是二肽基肽酶IV酶的抑制剂，并且在治疗或预防二肽基肽酶IV酶参与的疾病中有用，例如肥胖症和糖尿病，特别是2型糖尿病。本发明还涉及包括这些化合物的制药组合物以及在预防或治疗二肽基肽酶IV酶参与的这些疾病中使用这些化合物和组合物。
• US8653059B2
  申请人：——

  公开号：US8653059B2

  公开（公告）日：2014-02-18
• [EN] HETEROCYCLIC COMPOUNDS AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES EN TANT QU'INHIBITEURS DE DIPEPTIDYLPEPTIDASE-IV POUR LE TRAITEMENT OU LA PRÉVENTION DES DIABÈTES
  申请人：MERCK & CO INC

  公开号：WO2009025784A1

  公开（公告）日：2009-02-26

  The present invention is directed to substituted six-membered heterocyclic compounds of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as obesity and diabetes, particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.