4-(2-Methylpentyl)aniline

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(2-Methylpentyl)aniline
• 英文别名: 4-(2-methylpentyl)aniline
• 化学式: C₁₂H₁₉N
• 分子量: 177.29
• InChiKey: ZODGYRFQARPZGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Macrocyclic HOPO chelators
  申请人：LUMIPHORE, INC.

  公开号：US10352938B2

  公开（公告）日：2019-07-16

  The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds comprise hydroxypyridinonyl moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability.

  本发明提供了一类新型大环化合物以及金属（如镧系元素）离子与本发明化合物之间形成的配合物。优选的配合物在水介质中表现出高稳定性和高镧系离子发光量子产率，无需使用二级活化剂。优选化合物在其大环结构中包含羟基吡啶壬基，其特点是与抗体和蛋白质等多种多肽的非特异性结合率低得出奇，并且具有很高的动力学稳定性。
• Steroids and protein-conjugates thereof
  申请人：Regeneron Pharmaceuticals, Inc.

  公开号：US10711032B2

  公开（公告）日：2020-07-14

  Described herein protein steroid conjugates that are useful, for example, for the target-specific delivery of glucocorticoids (GCs) to cells.

  本文描述的蛋白质类固醇共轭物可用于向细胞靶向输送糖皮质激素（GCs）等。
• STEROIDS AND PROTEIN-CONJUGATES THEREOF
  申请人：Regeneron Pharmaceuticals, Inc.

  公开号：US20180155389A1

  公开（公告）日：2018-06-07

  Described herein protein steroid conjugates that are useful, for example, for the target-specific delivery of glucocorticoids (GCs) to cells.