alpha-(2-(Bis(1-methylethyl)amino)ethyl)-alpha-phenyl-2-pyridineacetamide hydrochloride | 54687-36-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: alpha-(2-(Bis(1-methylethyl)amino)ethyl)-alpha-phenyl-2-pyridineacetamide hydrochloride
• 英文别名: 4-[di(propan-2-yl)amino]-2-phenyl-2-pyridin-2-ylbutanamide;hydrochloride
• CAS: 54687-36-4
• 化学式: C21H30ClN3O
• 分子量: 375.9
• InChiKey: QFCSSPXLFBDRQQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.78
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  59.2
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Novel Pharmaceutical Compositions for Treating Chronic Pain and Pain Associated with Neuropathy
  申请人：Singh Chandra U.

  公开号：US20130189354A1

  公开（公告）日：2013-07-25

  The present invention relates to compositions and methods for treating pain wherein the compositions comprise a combination of tramadol or a pharmaceutically acceptable salt thereof, magnesium or a pharmaceutically acceptable salt thereof; and gabapentin or pregabalin. The therapeutic combination can further contain capsaicin or an ester of capsaicin.

  本发明涉及用于治疗疼痛的组合物和方法，其中所述组合物包括曲马多或其药学上可接受的盐、镁或其药学上可接受的盐；以及加巴嘌醇或普瑞巴林。治疗组合物还可以包含辣椒素或辣椒素酯。
• Disopyramide immunogens, antibodies, labeled conjugates, and related derivatives
  申请人：MILES LABORATORIES, INC.

  公开号：EP0113100A2

  公开（公告）日：1984-07-11

  Disopyramide immunogens, antibodies prepared therefrom, labeled conjugates, synthetic intermediates, and the use of such antibodies and labeled conjugates in immunoassays for determining disopyramide. The immunogens comprise disopyramide coupled by an ether linkage at a selected singular position on its phenyl ring to an immunogenic carrier material. Likewise, the labeled conjugates and synthetic intermediates are phenyl ether derivatives of disopyramide or precursors thereof. The antibody and labeled conjugates are particularly useful in homogeneous nonradioisotopic immunoassays for measuring disopyramide in biological fluids such as serum.

  地昔酰胺免疫原、由其制备的抗体、标记的共轭物、合成中间体，以及在测定地昔酰胺的免疫测定中使用这些抗体和标记的共轭物。免疫原包括在其苯基环上选定的奇异位置通过醚键与免疫原载体材料偶联的双吡酰胺。同样，标记的共轭物和合成中间体是二吡酰胺的苯基醚衍生物或其前体。抗体和标记的共轭物特别适用于均相非放射性同位素免疫测定，用于测量生物液体（如血清）中的地昔酰胺。
• Multi-layered, multiple unit pharmaceutical compositions
  申请人：Ranbaxy Laboratories Limited

  公开号：EP2886110A1

  公开（公告）日：2015-06-24

  The present invention relates to pharmaceutical compositions comprising multilayered multiple units and processes for the preparation thereof.

  本发明涉及由多层复方单元组成的药物组合物及其制备工艺。
• CONTROLLED RELEASE FORMULATION FOR WATER SOLUBLE DRUGS
  申请人：ANDRX PHARMACEUTICALS, INC.

  公开号：EP1124543A1

  公开（公告）日：2001-08-22
• EP1124543A4
  申请人：——

  公开号：EP1124543A4

  公开（公告）日：2004-03-31