(5R)-5-(3-hydroxy-4-phenylbut-1-enyl)-1-[4-(2H-tetrazol-5-ylsulfanyl)butyl]pyrrolidin-2-one

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: (5R)-5-(3-hydroxy-4-phenylbut-1-enyl)-1-[4-(2H-tetrazol-5-ylsulfanyl)butyl]pyrrolidin-2-one
• 化学式: C₁₉H₂₅N₅O₂S
• 分子量: 387.5
• InChiKey: CSYHDBJGSZIDDS-BHWOMJMDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  27
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  120
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Ep4 receptor agonist, compositions and methods thereof
  申请人：——

  公开号：US20040204590A1

  公开（公告）日：2004-10-14

  This invention relates to potent selective agonists of the EP 4 subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions which are related to elevated intraocular pressure in the eye of a patient. This invention further relates to the use of the compounds of this invention for mediating the bone modeling and remodeling processes of the osteoblasts and osteoclasts.

  这项发明涉及前列腺素E2受体EP4亚型的有效选择性激动剂，其在治疗青光眼和其他与患者眼内高眼压相关的疾病中的使用或配方。该发明还涉及利用本发明的化合物介导成骨细胞和破骨细胞的骨建模和重塑过程。
• EP1453503A4
  申请人：——

  公开号：EP1453503A4

  公开（公告）日：2005-03-30
• EP4 RECEPTOR AGONIST, COMPOSITIONS AND METHODS THEREOF
  申请人：Merck & Co., Inc.

  公开号：EP1453503A2

  公开（公告）日：2004-09-08
• [EN] EP4 RECEPTOR AGONIST, COMPOSITIONS AND METHODS THEREOF<br/>[FR] AGONISTE DU RECEPTEUR EP4, COMPOSITIONS ET PROCEDES ASSOCIES
  申请人：MERCK & CO INC

  公开号：WO2003047417A2

  公开（公告）日：2003-06-12

  This invention relates to potent selective agonists of the EP4 subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions which are related to elevated intraocular pressure in the eye of a patient. This invention further relates to the use of the compounds of this invention for mediating the bone modeling and remodeling processes of the osteoblasts and osteoclasts.