N-[(2S)-3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]-4-(4-cyclopropylbut-3-en-1-ynyl)benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[(2S)-3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]-4-(4-cyclopropylbut-3-en-1-ynyl)benzamide
• 化学式: C₁₉H₂₃N₃O₃
• 分子量: 341.4
• InChiKey: SECHGIDVBGVBQB-MRXNPFEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  104
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• ANTIBACTERIAL COMPOSITIONS
  申请人：Patten Phillip A.

  公开号：US20120283175A1

  公开（公告）日：2012-11-08

  The present invention provides a methods and pharmaceutical compositions useful for treating bacterial infections in humans and animals which comprises administering to a human or animal in need thereof, a synergistic combination of an inhibitor of LpxC and second antibacterial agent.
• [EN] COMBINATIONS COMPRISING A LPXC INHIBITOR AND AN ANTIBIOTIC FOR USE IN THE TREATMENT OF INFECTIONS CAUSED BY GRAM-NEGATIVE BACTERIA<br/>[FR] COMBINAISONS COMPRENANT UN INHIBITEUR DE LPXC ET UN ANTIBIOTIQUE À UTILISER DANS LE TRAITEMENT D'INFECTIONS INDUITES PAR DES BACTÉRIES À GRAM NÉGATIF
  申请人：ACHAOGEN INC

  公开号：WO2011005355A1

  公开（公告）日：2011-01-13

  The present invention provides a methods and pharmaceutical compositions useful for treating bacterial infections in humans and animals which comprises administering to a human or animal in need thereof, a synergistic combination of an inhibitor of LpxC and second antibacterial agent.