N~2~-ethyl-N~2~-[(4-methoxyphenyl)sulfonyl]-N-(2-methylphenyl)glycinamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N~2~-ethyl-N~2~-[(4-methoxyphenyl)sulfonyl]-N-(2-methylphenyl)glycinamide
• 英文别名: 2-[ethyl-(4-methoxyphenyl)sulfonylamino]-N-(2-methylphenyl)acetamide
• 化学式: C₁₈H₂₂N₂O₄S
• mdl: MFCD06634472
• 分子量: 362.4
• InChiKey: VVXJVDGDMMGROS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  84.1
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• COMPOSITIONS AND METHODS FOR INCREASING NEUROTROPHIC PEPTIDES
  申请人：Saint Louis College of Pharmacy

  公开号：EP2844251A2

  公开（公告）日：2015-03-11
• US9687488B2
  申请人：——

  公开号：US9687488B2

  公开（公告）日：2017-06-27
• [EN] COMPOSITIONS AND METHODS FOR INCREASING NEUROTROPHIC PEPTIDES<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR AUGMENTER DES PEPTIDES NEUROTROPHIQUES
  申请人：SAINT LOUIS COLLEGE OF PHARMACY

  公开号：WO2013166413A2

  公开（公告）日：2013-11-07

  A pharmaceutical composition is provided which includes a pharmaceutically acceptable excipient and a pharmaceutically and physically acceptable amount of a compound selected from the group consisting of Chemical Formulas I-IV as described herein, or a pharmaceutically acceptable salt thereof. Also provided are methods of increasing a level of a defined neurotrophic peptide in an organism or tissue comprising the administration of a pharmaceutically and physically acceptable amount of one or more of the compositions described above, and a method for treating a neurodegenerative disease in a subject in need thereof, the method comprising administering a therapeutically effective amount of the pharmaceutical composition of claim 1.