1-(p-tolylsulfinyl)but-3-en-2-ol | 63753-50-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(p-tolylsulfinyl)but-3-en-2-ol
• 英文别名: 1-(4-Methylphenyl)sulfinylbut-3-en-2-ol；1-(4-methylphenyl)sulfinylbut-3-en-2-ol
• CAS: 63753-50-4
• 化学式: C₁₁H₁₄O₂S
• 分子量: 210.297
• InChiKey: PTFGBBLNZFVBKW-UHFFFAOYSA-N

物化性质

• 沸点：
  385.6±42.0 °C(Predicted)
• 密度：
  1.19±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  56.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-(4-tolythio)-3-buten-2-ol 在 1,1-二氢过氧环己烷 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以81%的产率得到1-(p-tolylsulfinyl)but-3-en-2-ol
  参考文献：
  名称：

  A novel rapid sulfoxidation of sulfides with cyclohexylidenebishydroperoxide

  摘要：

  Cyclohexylidenebishydroperoxide was successfully used as the oxygen source for the oxidation of sulfides to sulfoxides for the first time. The sulfoxides were obtained in good to high yields without any detectable over-oxidation to sulfones under normal conditions. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.03.122

文献信息

• A visible-light-induced thiol addition/aerobic oxidation cascade reaction of epoxides and thiols for the synthesis of β-hydroxylsulfoxides
  作者：Marhaba Mamat、Changhong Liu、Dilshat Abdukerem、Ablimit Abdukader

  DOI：10.1039/d1ob01826d

  日期：——

  photochemical thiol addition/aerobic oxidation cascade reaction has been developed. This protocol enables efficient oxidative coupling of epoxides and thiols to access structurally valuable β-hydroxylsulfoxides. A broad range of functional groups are compatible to obtain moderate to good yields of the target products. Mechanistic studies revealed a sequential reaction pathway involving base-promoted thiol addition

  已经开发了光化学硫醇加成/好氧氧化级联反应。该协议使环氧化物和硫醇的有效氧化偶联能够获得结构上有价值的β-羟基亚砜。广泛的官能团可兼容以获得中等至良好的目标产物产率。机理研究揭示了一个顺序反应途径，包括碱促进硫醇将硫醇加成环氧化物和可见光诱导的硫醚有氧氧化。
• A novel rapid sulfoxidation of sulfides with cyclohexylidenebishydroperoxide
  作者：J. Jon Paul Selvam、V. Suresh、K. Rajesh、D. Chanti Babu、N. Suryakiran、Y. Venkateswarlu

  DOI：10.1016/j.tetlet.2008.03.122

  日期：2008.5

  Cyclohexylidenebishydroperoxide was successfully used as the oxygen source for the oxidation of sulfides to sulfoxides for the first time. The sulfoxides were obtained in good to high yields without any detectable over-oxidation to sulfones under normal conditions. (C) 2008 Elsevier Ltd. All rights reserved.