3-Morpholin-4-yl-1-[4-[3-(oxan-4-ylamino)phenyl]sulfanyl-2,3-bis(trifluoromethyl)phenyl]prop-2-en-1-one

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 3-Morpholin-4-yl-1-[4-[3-(oxan-4-ylamino)phenyl]sulfanyl-2,3-bis(trifluoromethyl)phenyl]prop-2-en-1-one
• 英文别名: 3-morpholin-4-yl-1-[4-[3-(oxan-4-ylamino)phenyl]sulfanyl-2,3-bis(trifluoromethyl)phenyl]prop-2-en-1-one
• 化学式: C₂₆H₂₆F₆N₂O₃S
• 分子量: 560.6
• InChiKey: OWQKHIKWRJVFHR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  38
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  76.1
• 氢给体数：
  1
• 氢受体数：
  12

文献信息

• Arylphenylamino-,Arylphenylamide-, and Arylphenylether-Sulfide Derivatives
  申请人：Chin Donovan

  公开号：US20070259863A1

  公开（公告）日：2007-11-08

  The present invention relates in part to compounds of formulas I and III: and pharmaceutically-acceptable salts and prodrugs thereof. These compounds can be useful for treating diseases such as inflammatory and immune diseases. The present invention also relates to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing immune response in a subject.

  本发明部分涉及式I和式III的化合物：以及其药学上可接受的盐和前药。这些化合物可用于治疗炎症和免疫性疾病。本发明还涉及包含这些化合物的制药组合物，以及抑制炎症或抑制受试者免疫反应的方法。
• ARYLPHENYLAMINO-, ARYLPHENYLAMIDE-, AND ARYLPHENYLETHER-SUFIDE DERIVATIVES
  申请人：ICOS Corporation

  公开号：EP1740565A2

  公开（公告）日：2007-01-10
• [EN] ARYLPHENYLAMINO-, ARYLPHENYLAMIDE-, AND ARYLPHENYLETHER-SULFIDE DERIVATIVES<br/>[FR] DERIVES DE SULFURE D'ARYLPHENYLAMINE, D'ARYLPHENYLAMIDE, ET D'ARYLPHENYLETHER
  申请人：ICOS CORP

  公开号：WO2005105770A2

  公开（公告）日：2005-11-10

  The present invention relates in part to compounds of formulas I and III: and pharmaceutically-acceptable salts and prodrugs thereof. These compounds can be useful for treating diseases such as inflammatory and immune diseases. The present invention also relates to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing immune response in a subject.