3-(4-Fluoro-2-methylphenyl)benzene-1,2-diamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(4-Fluoro-2-methylphenyl)benzene-1,2-diamine
• 英文别名: 3-(4-fluoro-2-methylphenyl)benzene-1,2-diamine
• 化学式: C₁₃H₁₃FN₂
• 分子量: 216.25
• InChiKey: QRUXIOUNSZNJRT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• FUSED CYCLIC UREA DERIVATIVES AS CRHR2 ANTAGONIST
  申请人：RaQualia Pharma Inc.

  公开号：EP3774739B1

  公开（公告）日：2022-05-11
• [EN] FUSED CYCLIC UREA DERIVATIVES AS CRHR2 ANTAGONIST<br/>[FR] DÉRIVÉS D'URÉE CYCLIQUE FUSIONNÉS UTILISÉS COMME ANTAGONISTES DE CRHR2
  申请人：RAQUALIA PHARMA INC

  公开号：WO2019198692A1

  公开（公告）日：2019-10-17

  The present invention relates to fused cyclic urea derivatives which have antagonistic activities against CRHR1 and/or CRHR2, and which are useful in the treatment or prevention of disorders and diseases in which CRHR1 and/or CRHR2 is involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CRHR1 and/or CRHR2 is involved.