2,3,4-Triiodobenzoic acid | 27836-94-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,3,4-Triiodobenzoic acid
• CAS: 27836-94-8
• 化学式: C₇H₃I₃O₂
• 分子量: 499.81
• InChiKey: CUDQZSUUZBNXGX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] SOLUBLE COMPLEXES OF DRUG ANALOGS AND ALBUMIN<br/>[FR] COMPLEXES SOLUBLES D'ANALOGUES DE MÉDICAMENT ET D'ALBUMINE
  申请人：FL THERAPEUTICS LLC

  公开号：WO2014121033A1

  公开（公告）日：2014-08-07

  The present invention provides novel, non-covalently bound complexes of serum albumin and analogs of poorly soluble drugs, such as camptothecin. The novel complexes are significantly more water-soluble than the camptothecin analogs and are useful as prodrug forms of the camptothecin analogs for the treatment of mammalian cell proliferative diseases, such as cancer.

  本发明提供了血清白蛋白与溶解度较差药物的类似物（如喜树碱）的新型非共价结合复合物。这些新型复合物比喜树碱类似物更易溶于水，并可用作喜树碱类似物的前药形式，用于治疗哺乳动物细胞增殖性疾病，如癌症。
• Radio-opaque compounds, compositions containing same and methods of their synthesis and use
  申请人：Pathak P. Chandrashekhar

  公开号：US20050036946A1

  公开（公告）日：2005-02-17

  Radio-opaque biodegradable compositions are formed by modifying terminal groups of synthetic and natural biodegradable polymers such as polylactones with iodinated moieties. The biodegradable property of the compositions renders them suitable for use in medical field such as drug delivery, imaging. Compounds disclosed in this invention exist as neat liquid. Certain compositions disclosed in this invention form hydrophobic iodine rich domains when dissolved in water, such domains provide better contrasting properties as well as ability to dissolve hydrophobic bioactive drugs. Certain iodinated moieties disclosed in the invention are capable of cross linking natural proteins in situ in presence of suitable catalysts and co-catalysts.

  放射不透明的可生物降解组合物是通过修改合成和天然可生物降解聚合物（如聚乳酸酯）的末端基团与碘化基团形成的。这些组合物的生物降解性使它们适用于医疗领域，如药物输送、成像等用途。本发明中披露的化合物存在于纯净液体中。本发明中披露的某些组合物在水中溶解时形成疏水碘富区域，这些区域提供更好的对比性能以及溶解疏水生物活性药物的能力。本发明中披露的某些碘化基团能够在适当催化剂和共催化剂存在的情况下交联天然蛋白质。
• CASCADE MACROMOLECULAR CONTRAST AGENTS FOR MEDICAL IMAGING
  申请人：Brasch C. Robert

  公开号：US20070248547A1

  公开（公告）日：2007-10-25

  The present invention provides macromolecular contrast media for diagnostic imaging modalities.

  本发明提供了用于诊断成像模式的高分子对比介质。
• 1,2,4-Triazole derivatives
  申请人：IMPERIAL CHEMICAL INDUSTRIES PLC

  公开号：EP0275704A1

  公开（公告）日：1988-07-27

  A thiophene, furan or tetrahydrofuran triazolyl derivative having the general formula (I) or (II) : and stereoisomers thereof, wherein R¹ is tertiary butyl, which may be optionally substituted with one or more halogen atoms; R² is the group :     -(CH₂)n-Z or      -CH=CH-X or      -C≡C-Z where n is an integer from 0 to 3 and Z is an optionally substituted thiophene, furan, or tetrahydrofuran ring; and X is an optionally substituted thiophene or tetrahydro­furan ring; and R³ is hydrogen or an alkyl group containing from 1 to 4 carbon atoms; and salts, esters and metal complexes of the compound of formula (I) and (II) wherein R³ is hydrogen.

  一种具有通式(I)或(II)的噻吩、呋喃或四氢呋喃三唑基衍生物及其立体异构体，其中R¹为三丁基，可以选择性地用一个或多个卤素原子取代；R²为基团：-(CH₂)n-Z或-CH=CH-X或-C≡C-Z，其中n为0到3的整数，Z为可选择性取代的噻吩、呋喃或四氢呋喃环；X为可选择性取代的噻吩或四氢呋喃环；R³为氢或含有1至4个碳原子的烷基基团；以及通式(I)和(II)化合物的盐、酯和金属配合物，其中R³为氢。
• PROCESS FOR PRODUCING AMINOALKYLSULFONIC ACID AND METHOD OF SALT EXCHANGE FOR SALT THEREOF
  申请人：Wako Pure Chemical Industries, Ltd.

  公开号：EP1548002A1

  公开（公告）日：2005-06-29

  The present invention relates to a method for efficiently producing an aminoalkylsulfonic acid in an industrial scale, and provides    "a process for producing an aminoalkylsulfonic acid represented by the general formula [2]:    wherein R1 and R2 are each independently a hydrogen atom, an alkyl group, an aryl group or an aralkyl group; and R3 and R4 are each independently a hydrogen atom or an alkyl group, comprising reacting an aminoalkylsulfonate salt represented by the general formula [1]:    wherein M is an alkali metal atom, an organic ammonium ion or an ammonium ion; and R1 to R4 are the same as described above,    an aqueous solution thereof, or a solution dissolving any one of them in a water-soluble organic solvent, selected from alcohols having 1 to 3 carbon atoms, carboxylic acids having 2 to 12 carbon atoms and dimethylformamide, with an organic acid; and    a method of salt exchange for an aminoalkylsulfonate salt represented by the general formula [1']:    wherein M' is an alkali metal atom, an organic ammonium ion or an ammonium ion; and R1 and R4 are the same as described above, comprising reacting an aminoalkylsulfonate salt represented by the above general formula [2] with a hydroxide represented by the general formula [6]:         M'OH     [6]    wherein M' is the same as described above, in an alcohol or water".

  本发明涉及一种在工业规模上高效生产氨基磺酸的方法，并提供“一种生产由通式[2]表示的氨基磺酸的方法：其中R1和R2分别是氢原子、烷基、芳基或芳基烷基；R3和R4分别是氢原子或烷基的氨基磺酸盐发生反应所得的方法，通式[1]表示如下：其中M是碱金属原子、有机铵离子或铵离子；R1至R4与上述相同，其水溶液或将任何一种溶解于水溶性有机溶剂中的溶液，所选的有1至3个碳原子的醇、有2至12个碳原子的羧酸和二甲基甲酰胺，与有机酸反应；以及氨基磺酸盐交换的方法，通式[1']表示如下：其中M'是碱金属原子、有机铵离子或铵离子；R1和R4与上述相同，包括将上述通式[2]表示的氨基磺酸盐与通式[6]表示的氢氧化物发生反应：M'OH [6]其中M'与上述相同，在醇或水中”。