4-amino-4-methyl-pentan-2-one oxime | 69151-99-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-amino-4-methyl-pentan-2-one oxime
• 英文别名: Diacetonamin-oxim；Methyl-(β-amino-isobutyl)-ketoxim；4-Amino-4-methyl-pentan-2-on-oxim；(NE)-N-(4-amino-4-methylpentan-2-ylidene)hydroxylamine
• CAS: 69151-99-1
• 化学式: C₆H₁₄N₂O
• 分子量: 130.19
• InChiKey: IHXACXWJGCBSCH-VMPITWQZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-amino-4-methyl-pentan-2-one oxime 在 sodium amalgam 、 溶剂黄146 作用下， 生成 2-甲基戊烷-2,4-二胺
  参考文献：
  名称：

  Kohn, Monatshefte fur Chemie, 1902, vol. 23, p. 14

  摘要：

  DOI：
• 作为产物：
  描述：

  双丙酮胺草酸盐 生成 4-amino-4-methyl-pentan-2-one oxime
  参考文献：
  名称：

  Harries; Adamiantz, Chemische Berichte, 1901, vol. 34, p. 301

  摘要：

  DOI：

文献信息

• Compositions for Chemical and Biological Defense
  申请人：Hatton Trevor Alan

  公开号：US20110027869A1

  公开（公告）日：2011-02-03

  One aspect of the present invention relates to reactive compositions and methods of use thereof, wherein a metal oxide cluster is used to connect a reactive group (or groups) to the surface of a substrate. In certain embodiments, the reactive group in the compositions decomposes organophosphate agents through nucleophilic hydrolysis. In certain embodiments, the reactive group in the compositions is bactericidal. Remarkably, the use of metal oxide clusters in the disclosed compositions and methods permits incorporation of higher quantities of nucleophilic and bactericidal groups without the difficulties associated with having to pretreat the substrate prior to its association with the reactive groups.

  本发明的一个方面涉及反应性组合物及其使用方法，其中金属氧化物簇用于将反应性基团（或基团）连接到基底表面上。在某些实施例中，组合物中的反应性基团通过亲核水解分解有机磷酸酯剂。在某些实施例中，组合物中的反应性基团具有杀菌作用。值得注意的是，所述组合物和方法中使用金属氧化物簇允许将更多的亲核和杀菌基团纳入其中，而无需在与反应性基团结合之前对基底进行预处理。
• Kohn, Chemische Berichte, 1901, vol. 34, p. 792
  作者：Kohn

  DOI：——

  日期：——
• CATALYTIC NANOPARTICLES FOR NERVE-AGENT DESTRUCTION
  申请人：Hatton T. Alan

  公开号：US20090218543A1

  公开（公告）日：2009-09-03

  The present invention relates to compositions and methods for sorbing (e.g., adsorption and chemisorption) and destroying organophosphate chemical agents. In certain embodiments, the invention contemplates the use of finely divided, modified nanoscale metal oxide particles. In one embodiment, a suspension of magnetite (Fe 3 O 4 ) nanoparticles modified with 2-pralidoxime or its polymeric analog, poly(4-vinylpyridine-N-phenacyloxime-co-acrylic acid), catalyzes the hydrolysis of organophosphate compounds at a neutral pH. The oxime-modified magnetite particles serve as a nano-sized particulate carrier with a powerful α-nucleophile, an oximate group, immobilized on its surface. The oxime-modified magnetite nanoparticles are colloidally stable at neutral pH and they are readily recovered from the aqueous milieu by high-gradient magnetic separation methods.
• US8772197B2
  申请人：——

  公开号：US8772197B2

  公开（公告）日：2014-07-08
• [EN] ANTIFUNGAL AGENTS FROM A STREPTOMYCETE<br/>[FR] AGENTS ANTIFONGIQUES SYNTHÉTISÉS PAR UN STREPTOMYCÈTE
  申请人：HARVARD COLLEGE

  公开号：WO2009026348A2

  公开（公告）日：2009-02-26

  A Streptomycete bacteria associated with the Southern Pine Beetle (SPB) has been found to synthesize a potent antifungal compound. The spectrum of activity of the isolated antifungal compound is similar to that of amphotericin, and the compound is approximately three-times more potent on a weight basis.