3-Hexan-3-ylpyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-Hexan-3-ylpyridine
• 英文别名: 3-hexan-3-ylpyridine
• 化学式: C₁₁H₁₇N
• 分子量: 163.26
• InChiKey: HDNPYNWTBFKSGU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Bile acid analogs as FXR/TGR5 agonists and methods of use thereof
  申请人：Enanta Pharmaceuticals, Inc.

  公开号：US10266560B2

  公开（公告）日：2019-04-23

  The present invention relates to compounds of Formula (I), and pharmaceutically acceptable salts thereof, where R1, R2, R3, R4, R5, R6, R7, R8 and m are as defined herein, pharmaceutical compositions comprising these compounds and methods of use of these compounds for treating a TGR5 mediated disease or condition.

  本发明涉及式（I）化合物、 及其药学上可接受的盐，其中 R1、R2、R3、R4、R5、R6、R7、R8 和 m 如本文所定义；包含这些化合物的药物组合物；以及使用这些化合物治疗 TGR5 介导的疾病或病症的方法。
• Substituted 2,4-diaminopyrimidines as kinase inhibitors
  申请人：Celgene CAR LLC

  公开号：US10828300B2

  公开（公告）日：2020-11-10

  The present invention provides 2,4-diaminopyrimidines, and/or pharmaceutically acceptable compositions thereof, as kinase inhibitors.

  本发明提供了作为激酶抑制剂的 2,4-二氨基嘧啶和/或其药学上可接受的组合物。
• Aryl cyclopropyl-amino-isoquinolinyl amide compounds
  申请人：Aerie Pharmaceuticals, Inc.

  公开号：US11312700B2

  公开（公告）日：2022-04-26

  Provided herein are arylcyclopropyl amino-isoquinoline amide compounds. In particular, the disclosure provides compounds that affect the function of kinases in a cell and that are useful as therapeutic agents or with therapeutic agents. The compounds of the disclosure are useful in the treatment of a variety of diseases and conditions including eye diseases such as glaucoma, cardiovascular diseases, diseases characterized by abnormal growth, such as cancers, and inflammatory diseases. The disclosure further provides compositions containing isoquinoline amide compounds.

  本文提供的是芳基环丙基氨基异喹啉酰胺化合物。特别是，本公开提供的化合物可影响细胞中激酶的功能，并可作为治疗剂或与治疗剂一起使用。本公开的化合物可用于治疗多种疾病和病症，包括眼部疾病（如青光眼）、心血管疾病、以异常生长为特征的疾病（如癌症）以及炎症性疾病。本公开进一步提供了含有异喹啉酰胺化合物的组合物。
• SUBSTITUTED CYCLOPROPYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP2464228B1

  公开（公告）日：2017-12-06
• PIPERAZINE-SUBSTITUTED [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP2938344B1

  公开（公告）日：2017-06-21