4-methoxy-N-{2-[(1E)-2-(pyridin-4-yl)ethenyl]phenyl}benzenesulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-methoxy-N-{2-[(1E)-2-(pyridin-4-yl)ethenyl]phenyl}benzenesulfonamide
• 英文别名: 4-methoxy-N-[2-(2-pyridin-4-ylethenyl)phenyl]benzenesulfonamide
• 化学式: C₂₀H₁₈N₂O₃S
• 分子量: 366.4
• InChiKey: CIJCDFMGZYKSSC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  76.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Heterocycle derivatives and drugs
  申请人：——

  公开号：US20030022884A1

  公开（公告）日：2003-01-30

  The object of the invention is to provide an excellent compound as a drug. The invention relates to a heterocyclic compound shown by the following formula: A-B-D-E [1] wherein A is heteroaryl or its oxide; B is ethenylene; D is optionally substituted phenylene; and E is a group of the formula: 1 wherein G is optionally substituted phenyl; and R is heteroaryl or heteroarylmethyl, or a group of the formula: 2 wherein n is an integer of 1 to 5; R 5 and R 6 are same or different and are independently selected from the group consisting of hydrogen, C 1 -C 6 alkyl, hydroxyalkyl, aminoalkyl; or R 5 and R 6 taken together with the adjacent nitrogen atom may form 5- to 7-membered cyclic amino group for —NR 5 R 6 or a salt thereof.

  本发明的目的是提供一种优良的化合物作为药物。该发明涉及一种由以下公式所示的杂环化合物：A-B-D-E [1]其中，A是杂芳基或其氧化物；B是乙烯基；D是可选取代的苯基；E是公式1的基团：其中，G是可选取代的苯基；R是杂芳基或杂芳基甲基，或者是公式2的基团：其中，n是1到5的整数；R5和R6相同或不同，且独立地选自由氢基、C1-C6烷基、羟基烷基、氨基烷基的群；或者R5和R6与相邻的氮原子一起形成5-至7-成员环氨基团的—NR5R6或其盐。
• Medicines
  申请人：——

  公开号：US20040209927A1

  公开（公告）日：2004-10-21

  A Vpr function regulating composition useful in the treatment of subjects infected with HIV or having AIDS, wherein the composition comprises an aminostilbazole derivative represented by the following formula [1] or a salt thereof as an active ingredient: A-B-D-E   [1] wherein A represents heteroaryl or an oxide thereof, B represents ethenylene, D represents phenylene, and E represents the formula: —N(R)—SO 2 -G wherein G represents phenyl, R represents hydrogen, alkyl, or —COR 0 (R 0 represents alkyl, alkoxy, aryloxy, 5- to 6-membered heteroaryl, heteroarylmethyl, aminoalkylene, or cyclic amino alkylene)or the like.

  一种调节组合物成分的Vpr功能，对治疗感染HIV或患有艾滋病的受试者有用，其中所述组合物包括下式表示的氨基苯乙烯类衍生物或其盐作为活性成分：A-B-D-E  [1]其中A代表杂环芳基或其氧化物，B代表乙烯基，D代表苯基，E代表式：—N(R)—SO2-G，其中G代表苯基，R代表氢、烷基或—COR0（R0代表烷基、烷氧基、芳基氧基、5-至6-成员杂环芳基、杂芳基甲基、氨基烷基或环状氨基烷基）或类似物。
• Remedial agent for chronic articular rheumatism
  申请人：——

  公开号：US20040116481A1

  公开（公告）日：2004-06-17

  The present invention relates to an excellent remedial agent for chronic rheumatoid arthritis, comprising an aminostilbazole derivative represented by the following formula [1] or a salt thereof as an active ingredient: A-B-D-E   [1] Wherein A represents heteroaryl or an oxide thereof, B represents ethenylene, D represents phenylene, E represents the formula: —N(R)SO 2 -G [wherein G represents phenyl, R represents hydrogen, alkyl, or —COR 0 (R 0 represents alkyl, alkoxy, aryloxy, 5- to 6-membered heteroaryl, heteroarylmethyl, aminoalkyleneor cyclicaminoalkylene) or the like].

  本发明涉及一种优良的慢性类风湿性关节炎治疗剂，其包括以下式子（1）所表示的氨基偏苯唑衍生物或其盐作为活性成分：A-B-D-E   （1）其中，A代表杂环芳基或其氧化物，B代表乙烯基，D代表苯基，E代表式：—N(R)SO2-G （其中，G代表苯基，R代表氢，烷基或—COR0（R0代表烷基，烷氧基，芳基氧基，5-至6-成员杂环芳基，杂芳基甲基，氨基烷基或环状氨基烷基）等）。
• AMINOSTILBAZOLE DERIVATIVE AND MEDICINE
  申请人：NIPPON SHINYAKU COMPANY, LIMITED

  公开号：EP0754682A1

  公开（公告）日：1997-01-22

  The invention relates to an aminostilbazole derivative of the following formula or a hydrate thereof, and a salt thereof. wherein R1 and R2 each represents hydrogen etc.; R3, R4, R13, and R14 each represents hydrogen, C1-3 acyl, halogen, hydroxy etc.; R5 represents hydrogen or hydroxy-substituted C1-3 alkyl etc.; R6 represents benzenesulfonyl substituted by C1-3 alkoxy etc.; ring Y represents phenyl etc.; ring Z represents 4-pyridyl, its oxide etc. The compound is useful for the treatment of various malignant tumors.

  本发明涉及下式的氨基苯并噻唑衍生物或其水合物及其盐。 其中 R1 和 R2 各自代表氢等；R3、R4、R13 和 R14 各自代表氢、C1-3酰基、卤素、羟基等；R5 代表氢或羟基取代的 C1-3 烷基等；R6 代表被 C1-3 烷氧基取代的苯磺酰基等；环 Y 代表苯基等；环 Z 代表 4-吡啶基及其氧化物等。 该化合物可用于治疗各种恶性肿瘤。
• HETEROCYCLE DERIVATIVES AND DRUGS
  申请人：Nippon Shinyaku Co., Ltd.

  公开号：EP1238974A1

  公开（公告）日：2002-09-11

  The object of the invention is to provide an excellent compound as a drug. The invention relates to a heterocyclic compound shown by the following formula:         A-B-D-E   [1] wherein A is heteroaryl or its oxide; B is ethenylene; D is optionally substituted phenylene; and E is a group of the formula:    wherein G is optionally substituted phenyl; and R is heteroaryl or heteroarylmethyl, or a group of the formula: wherein n is an integer of 1 to 5; R5 and R6 are same or different and are independently selected from the group consisting of hydrogen, C1-C6 alkyl, hydroxyalkyl, aminoalkyl; or R5 and R6 taken together with the adjacent nitrogen atom may form 5- to 7-membered cyclic amino group for -NR5R6 or a salt thereof.

  本发明的目的是提供一种用作药物的优良化合物。 本发明涉及一种下式所示的杂环化合物： A-B-D-E [1] 其中 A 是杂芳基或其氧化物 B 是乙烯基 D 是任选取代的亚苯基；以及 E 是式中的一个基团 其中 G 是任选取代的苯基；和 R 是杂芳基或杂芳基甲基，或一个式中的基团： 其中 n 为 1 至 5 的整数；R5 和 R6 相同或不同，且独立选自由氢、C1-C6 烷基、羟基烷基、氨基烷基组成的组；或 R5 和 R6 与相邻的氮原子一起可形成 5 至 7 元环氨基基团为 -NR5R6 或其盐。