3,5-Dimethylphenyl carbamate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,5-Dimethylphenyl carbamate
• 英文别名: (3,5-dimethylphenyl) carbamate
• 化学式: C₉H₁₁NO₂
• 分子量: 165.19
• InChiKey: SBTVLCPCSXMWIQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Enantioselective separation method
  申请人：Chekal P. Brian

  公开号：US20060020022A1

  公开（公告）日：2006-01-26

  This invention relates to a method for separating enantiomers of a substituted 2-trifluoromethyl-2H-chromene-3-carboxylic acid or ester, a substituted 2-trifluoromethyl-1,2-dihydro-quinoline-3-carboxylic acid or ester, a substituted 2-trifluoromethyl-2H-thiochromene-3-carboxylic acid or ester, a substituted 3-trifluoromethyl-3,4-dihydro-naphthalene-2-carboxylic acid or ester, or a pharmaceutically acceptable salt of the acids or esters, using enantioselective fractional crystallization, enantioselective high performance liquid chromatography, enantioselective steady state recycling chromatography, or enantioselective multicolumn chromatography.

  本发明涉及一种分离取代的2-三氟甲基-2H-色烯-3-羧酸或酯、取代的2-三氟甲基-1,2-二氢喹啉-3-羧酸或酯、取代的2-三氟甲基-2H-硫色烯-3-羧酸或酯、取代的3-三氟甲基-3,4-二氢萘-2-羧酸或酯、或药物可接受的盐的对映体分离方法，使用对映选择性分数结晶、对映选择性高效液相色谱、对映选择性稳态循环色谱或对映选择性多柱色谱。
• METHOD FOR THE PREPARATION OF ESCITALOPRAM
  申请人：Sommer Michael B.

  公开号：US20110065938A1

  公开（公告）日：2011-03-17

  A novel method is provided for the manufacture of escitalopram. The method comprises chromatographic separation of the enantiomers of citalopram or an intermediate in the production of citalopram using a chiral stationary phase such as Chiralpak™ AD or Chiralcel™ OD. Novel chiral intermediates for the synthesis of Escitalopram made by said method are also provided.

  提供了一种制造艾司西酞普兰的新方法。该方法包括使用手性固定相，如Chiralpak™ AD或Chiralcel™ OD，对西酞普兰的对映体或制备西酞普兰的中间体进行色谱分离。还提供了由该方法制造的用于合成艾司西酞普兰的新手性中间体。
• Method for the preparation of escitalopram
  申请人：Sommer B Michael

  公开号：US20050065207A1

  公开（公告）日：2005-03-24

  A novel method is provided for the manufacture of escitalopram. The method comprises chromatographic separation of the enantiomers of citalopram or an intermediate in the production of citalopram using a chiral stationary phase such as Chiralpak™ or Chiralcel™ OD. Novel chiral intermediates for the synthesis of Escitalopram made by said method are also provided.

  提供了一种制造艾司西酞普兰的新方法。该方法包括使用手性固定相（如Chiralpak™或Chiralcel™ OD）对西酞普兰的对映体或生产西酞普兰的中间体进行色谱分离。此外，还提供了通过该方法制造艾司西酞普兰的新手性中间体。
• [EN] METHOD FOR THE PREPARATION OF ESCITALOPRAM<br/>[FR] PROCEDE DE PREPARATION D'ESCITALOPRAM
  申请人：LUNDBECK & CO AS H

  公开号：WO2003006449A1

  公开（公告）日：2003-01-23

  A novel method is provided for the manufacture of escitalopram. The method comprises chromatographic separation of the enantiomers of citalopram or an intermediate in the production of citalopram using a chiral stationary phase such as ChiralpakTM AD or ChiralcelTM OD. Novel chiral intermediates for the synthesis of Escitalopram made by said method are also provided.

  提供了一种制造艾司西酞普兰的新方法。该方法包括使用手性固定相（如ChiralpakTM AD或ChiralcelTM OD）对西酞普兰的对映体或制备西酞普兰的中间体进行色谱分离。还提供了通过该方法制造艾司西酞普兰的新手性中间体。
• Chloro-, hydroxy- and alkoxysilane derivatives of polysaccharides or oligosaccharides, polymerizable and cross-linkable, their synthesis and their use as sources of novel support materials
  申请人：Institut Francais du Petrole

  公开号：US20020058763A1

  公开（公告）日：2002-05-16

  There are described chloro-, hydroxy- and alkoxysilane derivatives of polysaccharides or oligosaccharides as novel compounds which are polymerizable and cross-linkable, and a method for obtaining them; novel support materials obtained from said derivatives and containing said silane derivatives of polysaccharides or oligosaccharides chemically grafted by a covalent bond with the support and polymerized and cross-linked in a three-dimensional network and a method for obtaining them; as well as the use of said material supports in separation or in preparation of enantiomers, through employment in gaseous, liquid or supercritical chromatography, by electrophoresis, electrochromatography or by percolation processes through membranes containing said support materials.

  本文描述了聚糖或寡糖的氯基、羟基和烷氧基硅烷衍生物作为新化合物，这些化合物可聚合和交联，并提供了一种获得它们的方法；从这些衍生物中获得的新型支撑材料，其中包含通过共价键与支撑物化学接枝的聚糖或寡糖的硅烷衍生物，并在三维网络中聚合和交联，并提供了一种获得它们的方法；以及在分离或制备对映体中使用该材料支撑物的方法，通过在气态、液态或超临界色谱、电泳、电色谱或通过含有该支撑材料的膜的渗透过程中使用。