Benzylsulfanylurea

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Benzylsulfanylurea
• 化学式: C₈H₁₀N₂OS
• 分子量: 182.25
• InChiKey: LIJRFHKKYYYRHF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  80.4
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• IDO/TDO Inhibitor
  申请人：GENERAL INCORPORATED ASSOCIATION PHARMA VALLEY PROJECT SUPPORTING ORGANIZATION

  公开号：US20200239452A1

  公开（公告）日：2020-07-30

  A compound of formula (I) given below or a pharmaceutically acceptable salt of the compound is useful as an IDO/TDO inhibitor. Thus, the compound of formula (I) or the pharmaceutically acceptable salt of the compound can be used as, for example, a therapeutic agent for a disease or a disorder selected from tumor, infectious disease, neurodegenerative disorder, cataract, organ transplant rejection, autoimmune disease, postoperative cognitive impairment, and disease related to women's reproductive health [in the following formula (I), ring A represents an aromatic ring, an aliphatic ring, a heterocyclic ring, or a condensed ring of two or more rings selected from an aromatic ring, an aliphatic ring and a heterocyclic ring; X, R 1 and R 2 represent a substituent on a ring atom constituting ring A; m represents an integer of 0 to 6; X represents, for example, a halogen atom; and R 1 and R 2 are the same or different and are selected from, for example, the group consisting of groups of formula (a) or formula (b); and in the following formula (a) and formula (b), Y is selected from the group consisting of O, S, and Se, Z is selected from the group consisting of O, S, and Se, n represents an integer of 1 to 8, r represents an integer of 1 to 8, s represents an integer of 1 to 8, R 4 represents, for example, —C(═NH)—HN 2 , and R 6 represents, for example, a substituted or unsubstituted aryl group].

  以下公式（I）给出的化合物或该化合物的药学上可接受的盐可用作IDO/TDO抑制剂。因此，公式（I）的化合物或该化合物的药学上可接受的盐可用作，例如，用于肿瘤、传染病、神经退行性疾病、白内障、器官移植排斥、自身免疫疾病、术后认知障碍以及与女性生殖健康相关的疾病的治疗剂。在以下公式（I）中，环A代表芳香环、脂环、杂环或两个或更多个选自芳香环、脂环和杂环的缩合环的环；X、R1和R2代表构成环A的环原子上的取代基；m代表0到6的整数；X代表例如卤素原子；R1和R2相同或不同，选自例如由公式（a）或公式（b）组成的基团，而在以下公式（a）和公式（b）中，Y选自O、S和Se组成的基团，Z选自O、S和Se组成的基团，n表示1到8的整数，r表示1到8的整数，s表示1到8的整数，R4代表例如—C(═NH)—HN2，R6代表例如取代或未取代的芳基。
• Heteroarylakanoic acids as intergrin receptor antagonists
  申请人：——

  公开号：US20040092497A1

  公开（公告）日：2004-05-13

  The present invention relates to a class of compounds represented by formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of Formula (I), and methods of selectively antagonizing the &agr;&ngr;&bgr; 3 and/or the &agr;&ngr;&bgr; 5 integrin without significantly antagonizing the IIb/IIIa integrin. 1

  本发明涉及一类由式（I）表示的化合物或其药学上可接受的盐、包含式（I）化合物的制药组合物以及选择性拮抗&agr;&ngr;&bgr;3和/或&agr;&ngr;&bgr;5整合素而不显著拮抗IIb/IIIa整合素的方法。
• Heteroarylalkanoic acids as integrin receptor antagonists
  申请人：——

  公开号：US20020133023A1

  公开（公告）日：2002-09-19

  The present invention relates to a class of compounds represented by the Formula I 1 or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively antagonizing the &agr; V &bgr; 3 and/or the &agr; V &bgr; 5 integrin without significantly antagonizing the IIb/IIIa or &agr; V &bgr; 6 integrin.

  本发明涉及一类由式I1表示的化合物或其药学上可接受的盐，包括式I的药物组合物，并且涉及一种选择性拮抗&agr;V&bgr;3和/或&agr;V&bgr;5整合素而不显著拮抗IIb/IIIa或&agr;V&bgr;6整合素的方法。
• RECHARGEABLE BATTERY, FUNCTIONAL POLYMER, AND METHOD FOR SYNTHESIS THEREOF
  申请人：Uemachi Hiroshi

  公开号：US20130302679A1

  公开（公告）日：2013-11-14

  A safer rechargeable battery is offered. More concretely, The secondary battery composed to prevent the overcharge is offered. The electrolyte salt concentration of an electrolyte solution (solid or liquid) and those absolute quantity is controlled in the rechargeable battery in this execution form by using the anode material including n-dope domain and p-dope domain and in which many electron reactions are possible. In the anode of this rechargeable battery disconnection of lithium ion will take place first with the low potential (potential of n dope) at the time of charge, next, absorption of an anion will take place with as high potential (potential of p dope) as the point. Although the career of the ion current is only a lithium ion in the potential of n dope, in p dope potential, anion current flows through the anode side and lithium ion current flows through the cathode side. Thereby, before overcharge, the electrolytic concentration decreases, the internal resistance goes up, and the overcharge is avoided.

  提供了一种更安全的可充电电池。更具体地说，提供了由防止过充的次级电池组成的电池。在这种执行形式中，通过使用包括n掺杂区域和p掺杂区域的阳极材料，并且其中许多电子反应是可能的，来控制可充电电池中电解质溶液（固体或液体）的电解质盐浓度和绝对量。在这种可充电电池的阳极中，在充电时首先会发生锂离子的分离，其电位较低（n掺杂电位），接下来，吸收阴离子时电位会升高到较高（p掺杂电位）的点。虽然在n掺杂电位的离子电流只有锂离子，但在p掺杂电位时，阴离子电流通过阳极侧流动，锂离子电流通过阴极侧流动。因此，在过充之前，电解质浓度降低，内部电阻上升，从而避免了过充。
• KIT FOR ELECTRICAL WIRE WATER-SEALING MATERIAL, ELECTRICAL WIRE WATER-SEALING MATERIAL, WATER-SEALING MEMBER, WATER-SEALED ELECTRICAL WIRE, AND WATER-SEALING METHOD
  申请人：JSR Corporation

  公开号：EP2432092A1

  公开（公告）日：2012-03-21

  A kit for preparing a water-sealing agent, a water-sealing material for an electrical wire, a water-sealed electrical wire, and a water-sealing method, which are used for insulated wires and the like. A kit for preparing water-sealing material for electrical wire comprising compositions (I) and (II), wherein the water-sealing material for electrical wire is prepared by mixing them in an arbitrary ratio. (I): a liquid composition containing one or more components selected from the following components (A) to (C), and (D), without containing (E). (II): a liquid composition containing one or more components selected from the following components (A) to (C), and (E), without containing (D). (A) a urethane (meth)acrylate, (B) a compound having one ethylenically unsaturated group, (C) a radiation polymerization initiator, (D) an organic peroxide, and (E) a polymerization promotor; and water-sealing material for electrical wire: which is a liquid curing composition containing 5 to 50% by mass of(A), 30 to 90% by mass of (B), 0.01 to 10% by mass of (C), 0.1 to 5% by mass of (D), and 0.01 to 0.5% by mass of (E).

  一种用于制备绝缘电线等的水密封剂、电线水密封材料、水密封电线和水密封方法的试剂盒。 一种用于制备电线水密封材料的试剂盒，包括组合物 (I) 和 (II)，其中电线水密封材料是通过将它们以任意比例混合制备的。 (I)：一种液体组合物，含有选自以下组分（A）至（C）和（D）中的一种或多种组分，不含（E）。 (II)：一种液体组合物，含有选自以下组分（A）至（C）和（E）中的一种或 多种组分，不含（D）。 (A) 聚氨酯（甲基）丙烯酸酯、 (B) 具有一个乙烯不饱和基团的化合物、 (C) 辐射聚合引发剂、 (D) 有机过氧化物，和 (E) 一种聚合促进剂；以及 用于电线的水封材料：它是一种液体固化组合物，含有 5%至 50%（按质量计）的 （A）、30%至 90%（按质量计）的（B）、0.01%至 10%（按质量计）的（C）、0.1%至 5%（按质量计）的（D）和 0.01%至 0.5%（按质量计）的（E）。