4-Amino-6-anilinopyrimidine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-Amino-6-anilinopyrimidine
• 英文别名: 4-N-phenylpyrimidine-4,6-diamine
• 化学式: C₁₀H₁₀N₄
• 分子量: 186.21
• InChiKey: QHMLYBPYRIVJDA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  63.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• ANTIVIRAL COMPOSITIONS
  申请人：Verreck Geert

  公开号：US20070196478A1

  公开（公告）日：2007-08-23

  The present invention is concerned with pharmaceutical compositions of antiviral compounds which can be administered to a mammal, in particular a human, suffering from a viral infection. These compositions comprise particles obtainable by melt-extruding a mixture comprising one or more antiviral compounds and one or more appropriate water-soluble polymers and subsequently milling said melt-extruded mixture.

  本发明涉及抗病毒化合物的制药组合物，可用于治疗哺乳动物，特别是人类患有病毒感染的情况。这些组合物包括通过熔融挤出包含一种或多种抗病毒化合物和一种或多种适当的水溶性聚合物的混合物所获得的颗粒，并随后对该熔融挤出混合物进行研磨。
• ANTIVIRAL SOLID DISPERSIONS
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP1225874B1

  公开（公告）日：2006-02-01
• US7241458B1
  申请人：——

  公开号：US7241458B1

  公开（公告）日：2007-07-10
• [EN] ANTIVIRAL COMPOSITIONS<br/>[FR] COMPOSITIONS ANTIVIRALES
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2001022938A1

  公开（公告）日：2001-04-05

  The present invention is concerned with pharmaceutical compositions of antiviral compounds which can be administered to a mammal, in particular a human, suffering from a viral infection. These compositions comprise particles obtainable by melt-extruding a mixture comprising one or more antiviral compounds and one or more appropriate water-soluble polymers and subsequently milling said melt-extruded mixture.