3-(4-Methylphenyl)sulfonyl-2-[(4-methylphenyl)sulfonylmethyl]propanal

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(4-Methylphenyl)sulfonyl-2-[(4-methylphenyl)sulfonylmethyl]propanal
• 英文别名: 3-(4-methylphenyl)sulfonyl-2-[(4-methylphenyl)sulfonylmethyl]propanal
• 化学式: C₁₈H₂₀O₅S₂
• 分子量: 380.5
• InChiKey: VUDXEXHCVNGZRO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  102
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Method And Molecules
  申请人：MedImmune, LLC

  公开号：US20200206359A1

  公开（公告）日：2020-07-02

  The present invention provides a bioconjugation method and compounds for use therein. The bioconjugation method comprises the step of conjugating a biological molecule containing a first unsaturated functional group with a payload comprising a second unsaturated functional group, wherein the first and second unsaturated functional groups are complementary to each other such that conjugation is a reaction of said functional groups via a Diels-Alder reaction which forms a cyclohexene ring.
• PYRROLOBENZODIAZEPINE CONJUGATES
  申请人：MEDIMMUNE LIMITED

  公开号：US20210283141A1

  公开（公告）日：2021-09-16

  A conjugate of formula I: wherein Ab is a modified antibody having at least one free conjugation site on each heavy chain and each of R LL1 and R LL2 comprise the group:
• Method and Molecules
  申请人：MedImmune, LLC

  公开号：US20220371973A1

  公开（公告）日：2022-11-24

  The present invention provides conjugates of a first polypeptide and a second polypeptide wherein the link between the first polypeptide and the second polypeptide comprises the following moiety.