N'-[2-[2-[bis(pyridin-2-ylmethyl)amino]ethylamino]ethyl]ethane-1,2-diamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N'-[2-[2-[bis(pyridin-2-ylmethyl)amino]ethylamino]ethyl]ethane-1,2-diamine
• 化学式: C₁₈H₂₈N₆
• 分子量: 328.5
• InChiKey: RXBAHYRRWTUFCL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  24
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  79.1
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• TREPROSTINIL FORMULATIONS
  申请人：United Therapeutics Corporation

  公开号：EP3164155A1

  公开（公告）日：2017-05-10
• [EN] NOVEL CLONIDINE FORMULATION<br/>[FR] NOUVELLE FORMULATION DE CLONIDINE
  申请人：TRIS PHARMA INC

  公开号：WO2015076821A1

  公开（公告）日：2015-05-28

  An oral clonidine dosage unit providing a twenty-four hour extended release profile following a single dose administration is provided. The dosage unit comprises a pharmaceutically effective amount of a coated complex comprising clonidine bound to a cationic exchange resin, which is characterized by a twenty-four hour release profile with a single peak, wherein said oral clonidine dosage unit provides a therapeutically effective plasma concentration for at least about 70%, or at least 85% of the twenty- four hour period following the single dose administration. Both liquid and solid formulations are provided, as are methods of treating a patient by a single administration of a formulation of the invention so as to achieve a therapeutic effect for 24-hours.
• [EN] TREPROSTINIL FORMULATIONS<br/>[FR] FORMULATIONS DE TRÉPROSTINIL
  申请人：UNITED THERAPEUTICS CORP

  公开号：WO2015192030A1

  公开（公告）日：2015-12-17

  Provided are ion complexes comprising treprostinil and an ion-exchange resin, pharmaceutical formulations based on such complexes, and methods of treating diseases and conditions using the ion complexes and pharmaceutical formulations.