(R)-3-(1-Methylpyrrolidin-2-yl)pyridine bis((2R,3R)-2,3-dihydroxysuccinate) | 50915-69-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: (R)-3-(1-Methylpyrrolidin-2-yl)pyridine bis((2R,3R)-2,3-dihydroxysuccinate)
• 英文别名: (2R,3R)-2,3-dihydroxybutanedioic acid;3-[(2R)-1-methylpyrrolidin-2-yl]pyridine
• CAS: 50915-69-0
• 化学式: C18H26N2O12
• 分子量: 462.4
• InChiKey: RFEJUZJILGIRHQ-VGHAOCGRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  246
• 氢给体数：
  8
• 氢受体数：
  14

文献信息

• A COMPOSITION AND METHOD
  申请人：Nordbloom Ltd

  公开号：EP2688551A1

  公开（公告）日：2014-01-29
• [EN] A COMPOSITION AND METHOD<br/>[FR] COMPOSITION ET PROCÉDÉ
  申请人：NORDBLOOM LTD

  公开号：WO2012126941A1

  公开（公告）日：2012-09-27

  A method of preparing a mucoadhesive film formulation by preparing a film forming composition comprising lambda carrageenan as a film forming polymer, at a concentration of about 1-7 % by weight, a plasticizer at a concentration of about 1-15 % by weight, a biologically active substance, and purified water; distributing the film forming composition as a wet film layer onto a solid surface; and allowing the film layer to dry. A mucoadhesive film obtained by the method and a film dosage unit.