N2,N2-dimethyl-9H-fluorene-2,3-diamine | 108838-68-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: N2,N2-dimethyl-9H-fluorene-2,3-diamine
• 英文别名: 3-Amino-2-dimethylamino-fluoren；N²,N²-dimethyl-fluorene-2,3-diyldiamine；N²,N²-Dimethyl-fluoren-2,3-diyldiamin；3-Amino-2-dimethylaminofluorene；2-N,2-N-dimethyl-9H-fluorene-2,3-diamine
• CAS: 108838-68-2
• 化学式: C₁₅H₁₆N₂
• 分子量: 224.305
• InChiKey: CTOSRWHCZAOILV-UHFFFAOYSA-N

物化性质

• 熔点：
  155-156 °C
• 沸点：
  411.2±45.0 °C(Predicted)
• 密度：
  1.189±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-二甲基氨基-3-硝基芴 在 乙醇 、 镍 、 一水合肼 作用下， 生成 N2,N2-dimethyl-9H-fluorene-2,3-diamine
  参考文献：
  名称：

  Derivatives of Fluorene. IV. Raney Nickel-Hydrazine Hydrate Reduction of Various Mono- and Dinitrofluorene Derivatives; Some New 9-Substituted Fluorenes¹

  摘要：

  DOI：

  10.1021/jo01099a010

文献信息

• Therapeutic drug for lipid-peroxidation-induced diseases and screening method for therapeutic drugs for lipid-peroxidation-induced diseases
  申请人：Yamada Ken-ichi

  公开号：US11519893B2

  公开（公告）日：2022-12-06

  The present invention provides: an assay method that uses a compound represented by formula (I) as a fluorescent probe molecule and that is for detecting the lipid peroxidation suppression activity of a test compound; an assay kit that uses the assay method; a screening method that uses the assay method; and a pharmaceutical composition that is for the treatment, etc. of diseases (such as age-related macular degeneration) that are induced by lipid peroxidation reactions.

  本发明提供了：一种使用式（I）代表的化合物作为荧光探针分子的检测方法，该方法用于检测受试化合物的脂质过氧化抑制活性；一种使用该检测方法的检测试剂盒；一种使用该检测方法的筛选方法；以及一种药物组合物，该药物组合物用于治疗由脂质过氧化反应诱发的疾病（如老年性黄斑变性）等。
• THERAPEUTIC DRUG FOR LIPID-PEROXIDATION-INDUCED DISEASES AND SCREENING METHOD FOR THERAPEUTIC DRUGS FOR LIPID-PEROXIDATION-INDUCED DISEASES
  申请人：YAMADA Ken-ichi

  公开号：US20200158709A1

  公开（公告）日：2020-05-21

  The present invention provides: an assay method that uses a compound represented by formula (I) as a fluorescent probe molecule and that is for detecting the lipid peroxidation suppression activity of a test compound; an assay kit that uses the assay method; a screening method that uses the assay method; and a pharmaceutical composition that is for the treatment, etc. of diseases (such as age-related macular degeneration) that are induced by lipid peroxidation reactions.
• Derivatives of Fluorene. IV. Raney Nickel-Hydrazine Hydrate Reduction of Various Mono- and Dinitrofluorene Derivatives; Some New 9-Substituted Fluorenes¹
  作者：T. LLOYD FLETCHER、MOSES J. NAMKUNG

  DOI：10.1021/jo01099a010

  日期：1958.5