3-(2-Amino-1-methylimidazo[4,5-b]pyridin-6-yl)phenol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-(2-Amino-1-methylimidazo[4,5-b]pyridin-6-yl)phenol
• 英文别名: 3-(2-amino-1-methylimidazo[4,5-b]pyridin-6-yl)phenol
• 化学式: C₁₃H₁₂N₄O
• 分子量: 240.26
• InChiKey: LTIOTJGXUDBGSP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  77
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• XANTHINE DERIVATIVES, THEIR USE AS A MEDICAMENT, AND PHARMACEUTICAL PREPARATIONS COMPRISING THE SAME
  申请人：Max-Delbrück-Centrum für Molekulare Medizin

  公开号：EP3275885A1

  公开（公告）日：2018-01-31

  The invention relates to a xanthine derivative defined by chemical formula I or a salt thereof, its use as a medicament, especially for use in the treatment of serotonin-related diseases or disorders, and a pharmaceutical preparation comprising the xanthine derivative. The novel xanthine compounds are capable of inhibiting tryptophan hydroxylases (TPH) involved in the biosynthesis of serotonin and are effective in influencing the serotonin level in the body.

  本发明涉及一种由化学公式I定义的嘌呤衍生物或其盐，其用作药物，特别用于治疗与血清素相关的疾病或失调，以及包含该嘌呤衍生物的药物制剂。 这些新型的嘌呤化合物能够抑制参与血清素生物合成的色氨酸羟化酶（TPH），并且在影响体内的血清素水平方面有效。
• Xanthine derivatives, their use as a medicament, and pharmaceutical preparations comprising the same
  申请人：MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

  公开号：US10683309B2

  公开（公告）日：2020-06-16

  The invention relates to a xanthine derivative defined by chemical formula I or a salt thereof, its use as a medicament, especially for use in the treatment of serotonin-related diseases or disorders, and a pharmaceutical preparation comprising the xanthine derivative. The novel xanthine compounds are capable of inhibiting tryptophan hydroxylases (TPH) involved in the biosynthesis of serotonin and are effective in influencing the serotonin level in the body.

  本发明涉及一种由化学式 I 定义的黄嘌呤衍生物或其盐，其作为药物的用途，特别是用于治疗与血清素相关的疾病或紊乱，以及包含该黄嘌呤衍生物的药物制剂。 这种新型黄嘌呤化合物能够抑制参与血清素生物合成的色氨酸羟化酶（TPH），并能有效影响体内的血清素水平。
• [EN] XANTHINE DERIVATIVES, THEIR USE AS A MEDICAMENT, AND PHARMACEUTICAL PREPARATIONS COMPRISING THE SAME<br/>[FR] DÉRIVÉS DE LA XANTHINE, LEUR UTILISATION COMME MÉDICAMENT, ET PRÉPARATIONS PHARMACEUTIQUES LES COMPRENANT
  申请人：MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

  公开号：WO2016135199A1

  公开（公告）日：2016-09-01

  The invention relates to a xanthine derivative defined by chemical formula I or a salt thereof, its use as a medicament, especially for use in the treatment of serotonin-related diseases or disorders, and a pharmaceutical preparation comprising the xanthine derivative. The novel xanthine compounds are capable of inhibiting tryptophan hydroxylases (TPH) involved in the biosynthesis of serotonin and are effective in influencing the serotonin level in the body.