[(2S)-1-(3-methylphenyl)pyrrolidin-2-yl]methanamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: [(2S)-1-(3-methylphenyl)pyrrolidin-2-yl]methanamine
• 化学式: C₁₂H₁₈N₂
• 分子量: 190.28
• InChiKey: ZIZCXYOJKAFILH-LBPRGKRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Heterocyclic ureas, their preparation and their use as vanilloid receptor antagonists
  申请人：——

  公开号：US20040171639A1

  公开（公告）日：2004-09-02

  The invention relates to compounds of formula (I) having Vanilloid Receptor (VR1) antagonist activity, processes for their preparation, to compositions containing them and to their use in the treatment of various disorders.

  本发明涉及具有Vanilloid Receptor (VR1)拮抗活性的公式(I)化合物，其制备方法，含有它们的组合物以及它们在治疗各种疾病中的应用。
• HETEROCYCLIC UREAS, THEIR PREPARATION AND THEIR USE AS VANILLOID RECEPTOR ANTAGONISTS
  申请人：SMITHKLINE BEECHAM PLC

  公开号：EP1392651A1

  公开（公告）日：2004-03-03
• US6939891B2
  申请人：——

  公开号：US6939891B2

  公开（公告）日：2005-09-06
• [EN] HETEROCYCLIC UREAS, THEIR PREPARATION AND THEIR USE AS VANILLOID RECEPTOR ANTAGONISTS<br/>[FR] UREES HETEROCYCLIQUES, LEUR PREPARATION ET LEUR UTILISATION COMME ANTAGONISTES DU RECEPTEUR VANILLOIDE
  申请人：SMITHKLINE BEECHAM PLC

  公开号：WO2002090326A1

  公开（公告）日：2002-11-14

  The invention relates to compounds of formula (I) having Vanilloid Receptor (VR1) antagonist activity, processes for their preparation, to compositions containing them and to their use in the treatment of various disorders.