1-{[1-(4-Dimethylamino-phenyl)-meth-(E)-ylidene]-amino}-2,6-dimethyl-pyridinium; perchlorate

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-{[1-(4-Dimethylamino-phenyl)-meth-(E)-ylidene]-amino}-2,6-dimethyl-pyridinium; perchlorate
• 英文别名: 4-[(2,6-dimethylpyridin-1-ium-1-yl)iminomethyl]-N,N-dimethylaniline;perchlorate
• 化学式: C₁₆H₂₀N₃*ClO₄
• 分子量: 353.805
• InChiKey: BVOGOLDGPOMVSE-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.22
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  93.8
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1-Amino-2,6-dimethyl-pyridinium; perchlorate 、 对二甲氨基苯甲醛 以48%的产率得到1-{[1-(4-Dimethylamino-phenyl)-meth-(E)-ylidene]-amino}-2,6-dimethyl-pyridinium; perchlorate
  参考文献：
  名称：

  N-amination of 2,6-di-tert-butylpyridine

  摘要：

  Despite its low nucleophilicity 2,6-di-tert-butylpyridine (D TBP) easily undergoes N-amination. Other hidered pyridines react similarly. Comparison of the NMR carbon chemical shifts of 2,6-disubstituted 1-aminopyridinium perchlorates and those of the respective 1-methylpyridinium salts shows that the changes are parallel. 1-Amino-2,6-di-tert-butylpyridinium perchlorate does not react with p-dimethylaminobenzaldehyde. However, other hindered 1-(4'-dimethylaminobenzylideneamino)pyridinium salts were obtained by a standard procedure.

  DOI：

  10.1007/bf00811671

文献信息

• Girges; Hanna; Gawinecki, Arzneimittel Forschung, 1993, vol. 43, # 7, p. 756 - 760
  作者：Girges、Hanna、Gawinecki

  DOI：——

  日期：——
• N-amination of 2,6-di-tert-butylpyridine
  作者：Ryszard Gawinecki、Bernard Kanner

  DOI：10.1007/bf00811671

  日期：1994.1

  Despite its low nucleophilicity 2,6-di-tert-butylpyridine (D TBP) easily undergoes N-amination. Other hidered pyridines react similarly. Comparison of the NMR carbon chemical shifts of 2,6-disubstituted 1-aminopyridinium perchlorates and those of the respective 1-methylpyridinium salts shows that the changes are parallel. 1-Amino-2,6-di-tert-butylpyridinium perchlorate does not react with p-dimethylaminobenzaldehyde. However, other hindered 1-(4'-dimethylaminobenzylideneamino)pyridinium salts were obtained by a standard procedure.