Anethol sulfonic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Anethol sulfonic acid
• 英文别名: 2-methoxy-5-prop-1-enylbenzenesulfonic acid
• 化学式: C₁₀H₁₂O₄S
• 分子量: 228.27
• InChiKey: OMDLJUUFLOVMQL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  72
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Use of dermatan sulfates and/or desulfated heparins to treat or prevent heparinoid-induced autoimmune responses
  申请人：Cardin D. Alan

  公开号：US20050261241A1

  公开（公告）日：2005-11-24

  Dermatan sulfates and/or O-desulfated heparins useful in treating and preventing heparinoid-induced autoimmune responses, in particular heparin-induced thrombocytopenia (HIT) and its associated disease states. The dermatan sulfates comprise repeating disulfated and/or trisulfated disaccharide units of L-iduronic acid and N-acetyl-D-galactosamine. The O-desulfated heparins comprise heparin molecules selectively O-desulfated at the 2-O and/or 3-O positions of the uronic acid and glucosamine saccharide residues. Particularly effective dermatan sulfate HIT antagonists have a mean molecular weight of from about 2000 to about 10,000 Daltons.

  Dermatan硫酸和/或去硫化肝素在治疗和预防肝素样诱导的自身免疫反应中特别有用，特别是肝素诱导的血小板减少症（HIT）及其相关疾病状态。Dermatan硫酸由L-异硫酸和N-乙酰-D-半乳糖组成的重复二硫酸化和/或三硫酸化二糖单元。去硫化肝素由选择性地去硫化尿酸和葡萄糖胺糖残基的2-O和/或3-O位置的肝素分子组成。特别有效的Dermatan硫酸HIT拮抗剂的平均分子量约为2000至10000道尔顿。
• Anionic polymers as toxin binders and antibacterial agents
  申请人：Kurtz Isabelle Bacon Caroline

  公开号：US20060029568A1

  公开（公告）日：2006-02-09

  The present invention relates to a method of inhibiting a toxin in an animal, such as a human, by administering to the animal a therapeutically effective amount of a polymer having a plurality of pendant acid functional groups which are directly attached to the polymer backbone or attached to the polymer backbone by a spacer group. The spacer group can have a length in the range from 0 to about 20 atoms. The toxin is, typically, an exotoxin secreted by a pathogenic microorganism, such as a bacterium.

  本发明涉及一种抑制动物中毒素的方法，例如人类，通过向动物施用具有多个悬垂酸性功能基团的聚合物的治疗有效量，这些基团直接连接到聚合物骨架或通过一个间隔基团连接到聚合物骨架。间隔基团的长度可以在0到大约20个原子的范围内。毒素通常是由致病微生物（例如细菌）分泌的外毒素。
• Anionic Polymers as Toxin Binders and Antibacterial Agents
  申请人：Bacon Kurtz Caroline Isabelle

  公开号：US20100172861A1

  公开（公告）日：2010-07-08

  The present invention relates to a method of inhibiting a toxin in an animal, such as a human, by administering to the animal a therapeutically effective amount of a polymer having a plurality of pendant acid functional groups which are directly attached to the polymer backbone or attached to the polymer backbone by a spacer group. The spacer group can have a length in the range from 0 to about 20 atoms. The toxin is, typically, an exotoxin secreted by a pathogenic microorganism, such as a bacterium.

  本发明涉及一种通过向动物，如人类，投放具有多个挂基酸功能团的聚合物的治疗有效量来抑制动物体内毒素的方法。这些挂基酸功能团直接连接到聚合物骨架上，或通过一个间隔基团连接到聚合物骨架上，该间隔基团的长度可在0至约20个原子范围内。该毒素通常是由致病微生物（如细菌）分泌的外毒素。
• Salts of Clopidogrel With Polyanions and Their Use for Manufacturing Pharmaceutical Formulations
  申请人：Dähne Lars

  公开号：US20100311788A1

  公开（公告）日：2010-12-09

  The invention relates to salts of the active ingredient clopidogrel with polyanions. The salts are predominantly in amorphous form, and the polyanions have at least 4 negative charges.

  本发明涉及活性成分氯吡格雷与多聚阴离子的盐。这些盐主要以非晶态形式存在，而且多聚阴离子至少具有4个负电荷。
• Detection of microbial pathogens
  申请人：Wadley Technologies, Inc.

  公开号：EP0107070A1

  公开（公告）日：1984-05-02

  The invention relates to a method and means for detecting microbial pathogens in a sample body fluid which is suspected to contain antimicrobial factors by incorporating in the sample fluid an effective amount of an antimicrobial factor deactivating system which is noncidal to the microbial pathogens. The antimicrobial deactivating system includes aminoglycoside blocking agents, such as sodium polyanetholsulfonate and sodium amylosulfate; penicillin and cephalosporin deactivating agents, such as thioglycolate, glutathione, N-acetyl-cysteine and cysteine; a sulfa compound deactivating agent, such as p-aminobenzoic acid and enzymes which are specific to antibiotics. The antimicrobial factor deactivating system may also contain other compounds depending on the usage of the systems, for example lysing agents and anticoagulants.

  本发明涉及一种检测疑似含有抗菌因子的样本体液中微生物病原体的方法和手段，方法是在样本体液中加入有效量的抗菌因子失活系统，该系统对微生物病原体无杀灭作用。 抗菌剂失活系统包括氨基糖苷类阻断剂，如聚乙醇磺酸钠和氨基磺酸钠；青霉素和头孢菌素类失活剂，如硫代乙酸盐、谷胱甘肽、N-乙酰半胱氨酸和半胱氨酸；磺胺类化合物失活剂，如对氨基苯甲酸和抗生素特异性酶。 根据系统的用途，抗菌因子失活系统还可能含有其他化合物，例如裂解剂和抗凝剂。