5-N,10-N-bis(2-aminoethyl)-1,14,39,40,41,42,43,44-octazaoctacyclo[12.12.12.13,7.18,12.116,20.121,25.128,32.133,37]tetratetraconta-3(44),4,6,8,10,12(43),16(42),17,19,21,23,25(41),28(40),29,31,33,35,37(39)-octadecaene-5,10-dicarboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-N,10-N-bis(2-aminoethyl)-1,14,39,40,41,42,43,44-octazaoctacyclo[12.12.12.13,7.18,12.116,20.121,25.128,32.133,37]tetratetraconta-3(44),4,6,8,10,12(43),16(42),17,19,21,23,25(41),28(40),29,31,33,35,37(39)-octadecaene-5,10-dicarboxamide
• 化学式: C₄₂H₄₂N₁₂O₂
• 分子量: 746.9
• InChiKey: YHJVFSQJEUTTGH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  56
• 可旋转键数：
  6
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  194
• 氢给体数：
  4
• 氢受体数：
  12

文献信息

• Antimicrobial susceptibility testing and microbial identification
  申请人：SELUX DIAGNOSTICS, INC.

  公开号：US11339418B2

  公开（公告）日：2022-05-24

  Systems and methods for microbe identification (ID) in the context of phenotypic antimicrobial susceptibility testing (AST). Approaches for rapidly identifying polymicrobial samples are introduced that following perform one or more ID methods, such as matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF), PCR, or DNA hybridization, following sample incubation in two or more different media, including at least one selective media. Parallel ID and AST workflows are provided that may reduce the time from sample to AST result.

  表型抗菌药物敏感性检测（AST）中微生物鉴定（ID）的系统和方法。介绍了快速鉴定多微生物样本的方法，这些方法在样本在两种或两种以上不同培养基（包括至少一种选择性培养基）中培养后，执行一种或多种 ID 方法，如基质辅助激光解吸/电离飞行时间质谱（MALDI-TOF）、PCR 或 DNA 杂交。提供的并行 ID 和 AST 工作流程可缩短从样品到 AST 结果的时间。
• Spectroscopic Method For the Detection of Analytes
  申请人：Sellrie Frank

  公开号：US20080199972A1

  公开（公告）日：2008-08-21

  The present invention relates to methods for the detection of one or more analytes, in particular pathogens, viruses, prions, bacteria, parasites, pharmaceuticals, antibiotics, cytostatics, psychoactive substances, narcotics, analgesics, cardiac drugs, metabolites, coagulation inhibitors, hormones, interleukins and cytokines, performance-enhancing drugs, drugs, toxins, noxious substances, pesticides, insecticides, wood preservatives, herbicides, fungicides, explosives, vitamins and flavors by providing a conjugate of the analyte and an europium cryptate fluorophore or respectively a terbium cryptate fluorophore together with an antibody which is specific for the analyte and an antibody which is specific for the europium cryptate fluorophore or respectively the terbium cryptate fluorophore and by spectroscopically determining the fluorescence quenching which occurs when the analyte is added. Furthermore the present invention relates to conjugates of the analyte and the europium cryptate fluorophore or respectively terbium cryptate fluorophore as well as to a kit for the detection of analytes.
• Methods for Rapid Antibiotic Susceptibility Testing
  申请人：SeLux Diagnostics, Inc.

  公开号：US20170211121A1

  公开（公告）日：2017-07-27

  The present invention relates, in part, to methods and kits for rapidly determining antimicrobial susceptibility of microorganisms.
• Methods for Rapid Antimicrobial Susceptibility Testing
  申请人：SeLux Diagnostics, Inc.

  公开号：US20180179572A1

  公开（公告）日：2018-06-28

  The present invention relates, in part, to methods and kits for rapidly determining antimicrobial susceptibility of microorganisms.
• Sample Preparation for Antimicrobial Susceptibility Testing
  申请人：SELUX DIAGNOSTICS, INC.

  公开号：US20190301987A1

  公开（公告）日：2019-10-03

  The present disclosure provides novel methods for microbiological sample preparation from patients that yield high quality input material for antimicrobial susceptibility testing (AST) without the need for plate culture. Certain methods of this disclosure comprise multiple separation steps to purify microbial samples for use in ASTs.