5-{1-Hydroxy-2-[2-(4-hydroxy-phenyl)-1,1-dimethyl-ethylamino]-ethyl}-benzene-1,3-diol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-{1-Hydroxy-2-[2-(4-hydroxy-phenyl)-1,1-dimethyl-ethylamino]-ethyl}-benzene-1,3-diol
• 英文别名: 5-[1-Hydroxy-2-[[1-(4-hydroxyphenyl)-2-methylpropan-2-yl]amino]ethyl]benzene-1,3-diol
• 化学式: C₁₈H₂₃NO₄
• 分子量: 317.385
• InChiKey: BTWWDQYHZCQNJA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  93
• 氢给体数：
  5
• 氢受体数：
  5

文献信息

• Method of increasing the muscle/fat ratio in agricultural domestic animals
  申请人：DUPHAR INTERNATIONAL RESEARCH B.V

  公开号：EP0488435A1

  公开（公告）日：1992-06-03

  The invention relates to a method of improving the growth and the feed efficiency and of increasing the muscle/fat ratio of agricultural domestic animals, in particular bovine animals and sheep, by administering to the animals a composition which comprises as an active substance a compound of the general formula wherein: R₁is a phenylalkyl group the alkyl group of which comprises 1-3 carbon atoms and the phenyl group of which may be substituted with one or more substituents selected from the group consisting of hydroxy, methoxy, fluoro and methylsulphonylamino, or wherein R₁is a thienyl alkyl group or a tetrahydrofurylalkyl group the alkyl group of which comprises 1-3 carbon atoms; or wherein R₁is an optionally branched alkyl group having 1-8 carbon atoms which optionally is substituted with a C₁-C₄ alkoxy group, a hydroxy group, a C₁-C₄ alkoxycarbonyl group or a carboxy group; and wherein R₂ and R₃ are each independently methyl or ethyl; or an acid addition salt of the said compound. The invention further relates to a composition, in particular intended as a feed additive, which comprises such a phenylalkylamino derivative as an active substance.

  本发明涉及一种改善农用家畜，特别是牛和羊的生长和饲料效率以及提高肌肉/脂肪比率的方法，其方法是向动物施用一种组合物，该组合物的活性物质包括通式为以下的化合物 其中 R₁是苯基烷基，其烷基包含 1-3 个碳原子，苯基可被一个或多个选自羟基、甲氧基、氟基和甲磺酰氨基的取代基取代，或其中 R₁ 是由 1-3 个碳原子组成的噻吩基烷基或四氢呋喃基烷基；或 R₁ 是具有 1-8 个碳原子的任选支链烷基，该烷基任选被 C₁-C₄ 烷氧基、羟基、C₁-C₄ 烷氧羰基或羧基取代；且其中 R₂ 和 R₃ 各自独立地为甲基或乙基； 或上述化合物的酸加成盐。 本发明还涉及一种组合物，特别是用作饲料添加剂的组合物，其中包含作为活性物质的苯基烷基氨基衍生物。
• US5266589A
  申请人：——

  公开号：US5266589A

  公开（公告）日：1993-11-30