N-(4-Azido-2,3,5,6-tetrafluorobenzyl)-3-maleimidopropionamide | 139428-48-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-Azido-2,3,5,6-tetrafluorobenzyl)-3-maleimidopropionamide
• 英文别名: N-[(4-azido-2,3,5,6-tetrafluorophenyl)methyl]-3-(2,5-dioxopyrrol-1-yl)propanamide
• CAS: 139428-48-1
• 化学式: C14H9F4N5O3
• 分子量: 371.25
• InChiKey: QHTHQICZOPOYCT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  80.8
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• COVALENT FACTOR VII-TISSUE FACTOR COMPLEX
  申请人：Novo Nordisk Health Care AG

  公开号：EP2007417A1

  公开（公告）日：2008-12-31
• FVIIA-STF COMPLEXES EXHIBITING EXOSITE-MEDIATED SUPER ACTIVITY
  申请人：Novo Nordisk Health Care AG

  公开号：EP2831228A1

  公开（公告）日：2015-02-04
• Covalent Factor VII-Tissue Factor Complex
  申请人：Østergaard Henrik

  公开号：US20110040073A1

  公开（公告）日：2011-02-17

  The present invention relates to novel covalent complexes of a Factor VII polypeptide and a Tissue Factor polypeptide, in particular to such complexes which are functionally active and which have an enhanced proteolytic activity towards Factor X compared to the corresponding free Factor VII polypeptide as well as methods for production of these novel complexes.
• FVIIa-sTF complexes exhibiting exosite-mediated super activity
  申请人：Novo Nordisk HealthCare AG

  公开号：US20150044195A1

  公开（公告）日：2015-02-12

  Disclosed are disulphide-linked complexes of a soluble Tissue Factor (sTF) variant of SEQ ID NO:3 comprising the mutation G109C and a Factor VIIa variant of SEQ ID NO. 1, comprising the mutation Q64C and a mutation at position M306 that gives rise to a zymogen-like conformation in the Factor VIIa polypeptide. Said complexes may be used for the treatment of a coagulopathy.
• [EN] COVALENT FACTOR VII-TISSUE FACTOR COMPLEX<br/>[FR] COMPLEXE COVALENT DU FACTEUR VII ET DU FACTEUR TISSULAIRE
  申请人：NOVO NORDISK HEALTHCARE AG

  公开号：WO2007115953A1

  公开（公告）日：2007-10-18

  [EN] The present invention relates to novel covalent complexes of a Factor VII polypeptide and a Tissue Factor polypeptide, in particular to such complexes which are functionally active and which have an enhanced proteolytic activity towards Factor X compared to the corresponding free Factor VII polypeptide as well as methods for production of these novel complexes.
  [FR] La présente invention concerne de nouveaux complexes covalents d'un polypeptide du facteur VII et d'un polypeptide du facteur tissulaire, en particulier des complexes qui sont fonctionnellement actifs et font preuve d'une activité protéolytique accrue vis-à-vis du Facteur X, par comparaison avec le polypeptide démuni du facteur VII correspondant. L'invention porte également sur des procédés de production de ces nouveaux complexes.