1,1,1-Trifluoro-7-methyloctane

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氟化物
• 英文名称: 1,1,1-Trifluoro-7-methyloctane
• 英文别名: 1,1,1-trifluoro-7-methyloctane
• 化学式: C₉H₁₇F₃
• 分子量: 182.23
• InChiKey: PXNMFQREHIQECQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Design and synthesis of porphyrin materials for highly efficient organic photovoltaics
  申请人：Hong Kong Baptist University

  公开号：US20180006248A1

  公开（公告）日：2018-01-04

  The present disclosure relates to porphyrin small molecules substitutes designed and synthesized for bulk heterojunction (BHJ) organic solar cells (OSCs). Provided are synthesized materials with strong and ordered self-assembly property, leading to form bi-continuous, interpenetrating networks which are required for efficient charge separation and transport in organic solar cells. The power conversion efficiency (PCE) of the solar cells devices based on the embodiments of the present disclosure have the highest PCE among the solution-processed BHJ solar cell based on porphyrin small molecules up to date.

  本公开涉及为体异质结（BHJ）有机太阳能电池（OSCs）设计和合成的卟啉小分子替代物。提供了具有强大和有序自组装性质的合成材料，导致形成双连续、相互渗透的网络，这对于有机太阳能电池中的高效电荷分离和传输是必要的。基于本公开实施例的太阳能电池器件的光电转换效率（PCE）在迄今基于卟啉小分子的溶液处理BHJ太阳能电池中具有最高的PCE。
• Cyclic peptide antibiotics
  申请人：Genentech, Inc.

  公开号：US11279735B2

  公开（公告）日：2022-03-22

  Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of lipoprotein signal peptidase II (LspA), a key protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

  本文提供的是抗菌化合物，其中的化合物在某些实施方案中具有广谱生物活性。在各种实施方案中，这些化合物通过抑制脂蛋白信号肽酶 II（LspA）发挥作用，LspA 是细菌中的一种关键蛋白。还提供了使用本文所述化合物进行治疗的药物组合物和方法。
• KRAS G12C inhibitors and methods of using the same
  申请人：AMGEN INC.

  公开号：US11285135B2

  公开（公告）日：2022-03-29

  Provided herein are methods of treating cancer with KRAS G12C inhibitors of Formula I and compositions of the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

  本文提供了用式 I 的 KRAS G12C 抑制剂及其组合物治疗癌症的方法。这些抑制剂可用于治疗多种疾病，包括胰腺癌、结直肠癌和肺癌。
• KRAS G12C INHIBITORS AND METHODS OF USING THE SAME
  申请人：AMGEN INC.

  公开号：US20200069657A1

  公开（公告）日：2020-03-05

  Provided herein are methods of treating cancer with KRAS G12C inhibitors and compositions of the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
• CYCLIC PEPTIDE ANTIBIOTICS
  申请人：Genentech, Inc.

  公开号：US20200331968A1

  公开（公告）日：2020-10-22

  Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of lipoprotein signal peptidase II (LspA), a key protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.