6-Amino-2-[(4-fluorosulfonylbenzoyl)amino]hexanoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-Amino-2-[(4-fluorosulfonylbenzoyl)amino]hexanoic acid
• 英文别名: 6-amino-2-[(4-fluorosulfonylbenzoyl)amino]hexanoic acid
• 化学式: C₁₃H₁₇FN₂O₅S
• 分子量: 332.35
• InChiKey: ZEPXOCTVZGELSG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  135
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• CYCLIC PEPTIDE INHIBITORS OF HEDGEHOG PROTEINS
  申请人：University of Rochester

  公开号：US20210115087A1

  公开（公告）日：2021-04-22

  Cyclic peptide compounds are provided that can bind to one or more homologs of Hedghehog signaling proteins and block their interaction with the Patched receptor. These compounds are useful for suppressing Hedgehog-dependent stimulation of the Hedgehog pathway in cells and in living organisms. Methods for using the cyclic peptide compounds, and compositions comprising them, for treatment of cancers and other diseases which are characterized by aberrant Hedgehog-dependent activation of the Hedgehog pathway and/or which can benefit from chemical suppression of Hedgehog-dependent signaling are also disclosed.