IWR 1-exo

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: IWR 1-exo
• 英文别名: 4-(3,5-dioxo-4-azatricyclo[5.2.1.02,6]dec-8-en-4-yl)-N-quinolin-8-ylbenzamide
• 化学式: C₂₅H₁₉N₃O₃
• 分子量: 409.4
• InChiKey: ZGSXEXBYLJIOGF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  31
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  79.4
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• glycosylated protein of an extra-cellular matrix for use in a method of treating an ischemic heart of a human or animal subject in need thereof
  申请人：Fraunhofer Gesellschaft zur Förderung der angewandten Forschung e.V.

  公开号：EP2832362A1

  公开（公告）日：2015-02-04

  The present invention relates to a glycosylated protein of an extra-cellular matrix, preferably of a mammalian extra-cellular matrix for use in a method of treating an ischemic heart of a human or animal subject in need thereof, a pharmaceutical composition comprising said glycosylated protein and a method for the in vitro production of differentiated cardiomyocytes.

  本发明涉及一种细胞外基质（最好是哺乳动物细胞外基质）的糖基化蛋白质，用于治疗有需要的人或动物的缺血性心脏的方法；还涉及一种包含所述糖基化蛋白质的药物组合物和一种体外生产分化心肌细胞的方法。
• METHOD FOR INDUCING DIFFERENTIATION OF ALVEOLAR EPITHELIAL CELLS
  申请人：Kyoto University

  公开号：EP3266864A1

  公开（公告）日：2018-01-10

  This invention provides a method for stably producing type II alveolar epithelial cells from pluripotent stem cells. Specifically, the invention relates to a method for producing type II alveolar epithelial cells from pluripotent stem cells comprising steps of: (1) culturing pluripotent stem cells in a medium containing activin A and a GSK3β inhibitor; (2) culturing the cells obtained in Step (1) in a medium containing a BMP inhibitor and a TGFβ inhibitor; (3) culturing the cells obtained in Step (2) in a medium containing BMP4, retinoic acid, and a GSK3β inhibitor; (4) culturing the ventral anterior foregut cells obtained in Step (3) in a medium containing a GSK3β inhibitor, FGF10, KGF, and a NOTCH signal inhibitor; and (5) subjecting the alveolar epithelial progenitor cells obtained in Step (4) to three-dimensional culture in a medium containing a steroid drug, a cAMP derivative, a phosphodiesterase inhibitor, and KGF.

  本发明提供了一种用多能干细胞稳定生产II型肺泡上皮细胞的方法。具体而言，本发明涉及一种用多能干细胞生产 II 型肺泡上皮细胞的方法，包括以下步骤：(1) 在含有激活素 A 和 GSK3β 抑制剂的培养基中培养多能干细胞；(2) 在含有 BMP 抑制剂和 TGFβ 抑制剂的培养基中培养步骤(1)中获得的细胞；(3) 在含有 BMP4、维甲酸和 GSK3β 抑制剂的培养基中培养步骤(2)中获得的细胞；(4) 在含有 GSK3β 抑制剂、FGF10、KGF 和 NOTCH 信号抑制剂的培养基中培养步骤(3)中获得的腹侧前肠细胞；以及 (5) 将步骤(4)中获得的肺泡上皮祖细胞置于含有类固醇药物、cAMP 衍生物、磷酸二酯酶抑制剂和 KGF 的培养基中进行三维培养。
• METHOD FOR SUPPRESSING DIFFERENTIATION OF PLURIPOTENT STEM CELLS
  申请人：Kaneka Corporation

  公开号：EP4105319A1

  公开（公告）日：2022-12-21

  Pluripotent stem cells are suspension-cultured with the undifferentiated state thereof maintained. In suspension culture of pluripotent stem cells, the undifferentiated state is maintained by the presence of a PKC inhibitor, especially, a PKCβ inhibitor, and a tankyrase inhibitor (TNKS inhibitor).

  多能干细胞是在保持未分化状态下进行悬浮培养的。在多能干细胞的悬浮培养过程中，PKC 抑制剂（尤其是 PKCβ 抑制剂）和罐酸酶抑制剂（TNKS 抑制剂）的存在可维持多能干细胞的未分化状态。
• Antiviral axin stabilizer
  申请人：The Board of Regents for Oklahoma State University

  公开号：US10064862B2

  公开（公告）日：2018-09-04

  Methods and compositions for preventing and/or treating viral infections are provided. The methods involve administering an agent that stabilizes or enhances Axin1 activity, e.g. and agent that inhibits tankyrase. Administration of the agent stimulates or increases interferon activity, thereby preventing or lessening at least one symptom of virus infection. The virus infection may be caused by a respiratory virus such as influenza vims.

  提供了预防和/或治疗病毒感染的方法和组合物。这些方法包括施用稳定或增强 Axin1 活性的制剂，例如抑制 tankyrase 的制剂。给药可刺激或增加干扰素活性，从而预防或减轻病毒感染的至少一种症状。病毒感染可由呼吸道病毒引起，如流感病毒。
• Methods for epicardial differentiation of human pluripotent stem cells
  申请人：Wisconsin Alumni Research Foundation

  公开号：US10131878B2

  公开（公告）日：2018-11-20

  Methods for generating high-yield, high-purity epicardial cells are described. Wnt/β-catenin signaling is first activated in human cardiac progenitor cells, by, for example, inhibiting Gsk-3 to induce differentiation into epicardial cells. Methods for long-term in vitro maintenance of human cardiac progenitor cell-derived epicardial cells and method comprising chemically defined, xeno-free, and albumin-free culture conditions are also provided.

  本文介绍了产生高产、高纯度心外膜细胞的方法。Wnt/β-catenin 信号首先在人类心脏祖细胞中激活，例如通过抑制 Gsk-3 来诱导分化为心外膜细胞。此外，还提供了长期体外维持人心脏祖细胞衍生的心外膜细胞的方法，以及包括化学定义、无异种和无白蛋白培养条件的方法。